IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1966;5:166-169.)
© 1966 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by REDDY, D. V. N.
Right arrow Articles by NATHORST-WINDAHL, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by REDDY, D. V. N.
Right arrow Articles by NATHORST-WINDAHL, G.

Comparison of Amino Acid Transport in Ocular Structures of Rabbits Made Diabetic by Alloxan and Pancreatectomy

D. V. N. REDDY 1, V. EVERETT KINSEY 1, and G. NATHORST-WINDAHL 1

1 Kresge Eye Institute of Wayne State University School of Medicine, Detroit, Mich., and Patologiska Institutionen, University of Uppsala, Uppsala, Sweden

Whether alloxan or diabetes is responsible for the lowered concentration of amino acids in aqueous humor and lenses of rabbits made diabetic by this drug was investigated. The rate of accumulation of 14C-cycloleucine (l-amino cyclopentane carboxylic acid) in both posterior aqueous and lens was depressed to essentially the same degree in rabbits made diabetic by pancreatectomy or by alloxan. The uptake of cycloleucine in lenses cultured in the presence of alloxan was unaffected. It is concluded that some factor associated with diabetes, probably elevated level of glucose, is responsible for the altered rate of accumulation across both the ciliary epithelium and the lens rather than a direct toxic effect of alloxan






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1966 by the Association for Research in Vision and Ophthalmology