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(Investigative Ophthalmology and Visual Science. 1966;5:170-175.)
© 1966 by The Association for Research in Vision and Ophthalmology, Inc.

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The Effects of Pilocarpine on the Dynamics of Aqueous Humor in a Primate (Macaca Irus)

ANDERS BILL 1 and PER-ERIK WåLINDER 1

1 Departments of Pharmacology and Ophthalmology, University of Uppsala, Uppsala, Sweden

Albumin labelled with 131I and 125I was used to determine at the same time and, in both eyes the rates of conventional and uveoscleral bulk drainage of aqueous humor in cynomolgus monkeys under pentobarbital anesthesia. With 10-4 M per liter of pilocarpine in the anterior chamber, the rate of conventional bulk drainage of aqueous humor was 0.98 ± 0.19 µl per minute as compared with 0.56 ± 0.12 µl per minute in the control eye. The rate of uveoscleral bulk drainage was 0.07 ± 0.01 µl per minute in the pilocarpine eye, and 1.04 ± 0.14 µl per minute in the control eye. The mean rate of aqueous humor production in the pilocarpine eye, 1.05 ± 0.17 µl per minute, was significantly lower than that in the control eye, 1.60 - 0.14 µl per minute. The average increase in facility that was produced by pilocarpine toas 0.109 ± 0.042 µl per minute per millimeters of mercury; it was probably significant. The out flow pressure in the pilocarpine eye was calculated to be about 3.7 mm. Hg, that in the control eye was about 2.6 mm. Hg. The intraocular pressure was 2.64 ± 0.71 mm. Hg higher on the pilocarpine side. Part of the rise in intraocular pressure was due to the reduction in uveoscleral drainage of aqueous humor that caused an increased fioio by way of conventional routes. The reduction in aqueous humor formation in the pilocarpine eyes was related to the rise in intraocular pressure, and probably caused by this rise




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