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(Investigative Ophthalmology and Visual Science. 1966;5:176-185.)
© 1966 by The Association for Research in Vision and Ophthalmology, Inc.

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Quantitative Study of Pupil Response to Miotic Drugs

Kenneth N. Ogle 1, Robert A. Whisnant 1, and Jane B. Hazelrig 1

1 Mayo Clinic and Mayo Foundation, Section of Biophysics (Dr. Ogle and Mrs. Hazelrig), and the Mayo Graduate School of Medicine (University of Minnesota) (Dr. Whisnant) Rochester, Minn.

A model by which the time relationship of the miotic effects of three drugs (pilocarpine, eserine, and carbachol) can be described is discussed in a two compartment analysis. The data obtained on six subjects were subjected to a curve-fitting procedure with a computer, from which the parameters of the equation describing the miosis-time curve could be obtained. With these the pertinent characteristics of the responses to the drugs coidd be compared






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Copyright © 1966 by the Association for Research in Vision and Ophthalmology