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(Investigative Ophthalmology and Visual Science. 1966;5:560-567.)
© 1966 by The Association for Research in Vision and Ophthalmology, Inc.

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Effect of age on cell division, 3H-thymidine incorporation, and diurnal rhythm in the lens epithelium of rats

LUDWIG VON SALLMANN 1 and PATRICIA GRIMES 1

1 Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, United States Department of Health, Education, and Welfare Bethesda, Md.

The rapid growth of the rat lens during the first year of life is accompanied by only small changes in the size of the epithelial population. The cell layer adapts to the great expansion of lens surface area by spreading of the cells. Cell proliferation as represented in the mitotic and 3H-labeled cell indices decreases during this period of life. Animals killed in the forenoon showed a reduction of 3H-thymidine incorporation with age which surpassed the fall of mitotic activity. Age-dependent changes in the ratio of labeled cells to mitosis can be explained in part by a shift in the timing of diurnal fluctuations of mitosis in older animals. Variation of 3H-thymidine incorporation associated with the diurnal rhythm in mitotic activity could not be detected with 6 hour sampling intervals




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