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(Investigative Ophthalmology and Visual Science. 1966;5:636-639.)
© 1966 by The Association for Research in Vision and Ophthalmology, Inc.

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Antagonists of DNA synthesis in corneal epithelial cells of the dogfish

Seymour Zigman 1, Joan Tuttle 1, and Sidney Lerman 1

1 Department of Surgery, Division of Ophthalmology, and Department of Biochemistry, University of Rochester School of Medicine and Dentistry Rochester, N.Y.

The epithelial cells of the cornea of the dogfish continue to incorporate thymidine into their DNA during incubation in elasmobranch Ringer's solutions under appropriate conditions. This incorporation of H3 thymidine can be markedly inhibited by including IUDR in the medium, or by preirradiation of the cells with gamma rays or UV light






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