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(Investigative Ophthalmology and Visual Science. 1968;7:53-66.)
© 1968 by The Association for Research in Vision and Ophthalmology, Inc.

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Studies on the Cornea

VII. Effects of Perfusion with a Ca++-free Medium on the Corneal Endothelium

GORDON I. KAYE 1, SAIICHI MISHIMA 1, JEANNE D. COLE 1, and NANCY WEBER KAYE 1

1 F. Higginson Cabot Laboratory of Electron Microscopy, Division of Surgical Pathology, Departments of Surgery and Pathology; and the Department of Ophthalmology, College of Physicians and Surgeons, Columbia University New York, N.Y.

Paired isolated corneas were perfused in vitro with a modified KEI medium according to the method of Mishima and Kudo. One eye of each pair was perfused with the complete medium and the other with a Ca++-free medium. Progressive corneal swelling occurred in the Ca++-free medium. The swollen corneas had a greatly increased passive permeability to nontransported nonelectrolytes, suggesting a physical change in the permeability barrier. Electron microscopic examination of the swollen corneas showed that the apical functional complexes (terminal bars) underwent progressive disintegration in the Ca++-free medium and that the degree of this disintegration was correlated with the degree of swelling.

Note:

Recipient of a Career Scientist Award of the Health Research Council of the City of New York, under Contract No. I-320.




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T. Senoo, Y. Obara, and N. C. Joyce
EDTA: A Promoter of Proliferation in Human Corneal Endothelium
Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 2930 - 2935.
[Abstract] [Full Text]


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