IOVS Arteriosclerosis, Thrombosis, and Vascular Biology
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(Investigative Ophthalmology and Visual Science. 1968;7:334-346.)
© 1968 by The Association for Research in Vision and Ophthalmology, Inc.

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Distribution of 5,5-Dimethyl-2,4-Oxazolidinedione (DMO) in Intraocular Fluids

V. Effect of Plasma Level, Probenecid, and Dichlorphenamide on Time Course

MARGUERITE A. CONSTANT 1

1 Department of Ophthalmology and the Oscar Johnson Institute, Washington University Medical School St. Louis, Mo.

The kinetics of penetration of DMO into intraocular fluids at different plasma levels or after the administration of probenecid or dichlorphenamide have been studied. Many similarities were found to other systems which have been studied. The data provided further evidence for the probability that DMO is secreted out of the eye and that this mechanism is inhibited by probenecid and dichlorphenamide.







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Copyright © 1968 by the Association for Research in Vision and Ophthalmology