IOVS Arteriosclerosis, Thrombosis, and Vascular Biology
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(Investigative Ophthalmology and Visual Science. 1968;7:441-451.)
© 1968 by The Association for Research in Vision and Ophthalmology, Inc.

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Characterization of the Transport of Neutral Amino Acids by the Calf Lens

D. BRASSIL 1 and H. L. KERN 1

1 Department of Ophthalmology, Albeit Einstein College of Medicine of Yeshiva University, New York, N.Y.

A number of selective sites have been found in the calf lens at which cellular transport of the neutral amino acids takes place. The characterization of two of these, the A-site and the Lsite, agrees with that of Christensen for these sites in other tissues. The existence of a third, site, X, was also demonstrated. The X-site was selective for the small amino acids, glycine and sarcosine, and alanine to a lesser extent. Most of the entry of the neutral amino acids occurred at these sites, with the residual or so-called unsaturable component usually constituting a small proportion of the total cellular uptake.






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