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(Investigative Ophthalmology and Visual Science. 1968;7:501-519.)
© 1968 by The Association for Research in Vision and Ophthalmology, Inc.

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Structural Alterations Affecting Transparency in Swollen Human Corneas

JEROME N. GOLDMAN 1, GEORGE B. BENEDEK 1, CLAES H. DOHLMAN 1, and BARBARA KRAVITT 1

1 Department of Cornea Research, Institute of Biological and Medical Sciences, Retina Foundation Boston, Mass. Cornea Service, Massachusetts Eye and Ear Infirmary Boston, Mass. Department of Physics, Massachusetts Institute of Technology Cambridge, Mass.

A simple discussion of the theory of the diffraction and scattering of light is presented. This theory is used to explain corneal transparency in terms of microscopic structure, and leads to the prediction that characteristic morphological changes would be found in swollen, opaque corneas. Specifically, it is to be expected that opaque corneas will show marked fluctuations in the index of refraction over distances comparable to, or larger than, the wavelength of light. Examination of all layers of pathological surgical specimens demonstrated morphological changes which were consistent with predictions of this theory.

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Address reprint requests to: Department of Ophthalmology, George Washington University School of Medicine, 239 Warwick Clinic, 2300 K St. N.W., Washington, D. C. 20037.




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