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(Investigative Ophthalmology and Visual Science. 1969;8:133-149.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

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Electron Microscopic Study of Galactose-Induced Cataract

TOICHIRO KUWABARA 1, JIN H. KINOSHITA 1, and DAVID G. COGAN 1

1 Howe Laboratory of Ophthalmology, Harvard University Medical School and Massachusetts Eye and Ear Infirmary, Boston, Mass. 02114

Cataractous lenses induced by galactose feeding were studied electron microscopically. The early changes were increased reactivity of the epithelium, edema of the lens cells, and intercellular cyst formation in the bow and posterior zones. These changes continued with further feeding of galactose until the lens cells became irreversibly damaged. The reactive epithelial cells formed marked cell proliferations.

Key Words: galactose cataract • crystalline lens • lenticular cyst • subcapsular vacuoles of the lens • infrastructure




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T. W. White, D. A. Goodenough, and D. L. Paul
Targeted Ablation of Connexin50 in Mice Results in Microphthalmia and Zonular Pulverulent Cataracts
J. Cell Biol., November 2, 1998; 143(3): 815 - 825.
[Abstract] [Full Text] [PDF]


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