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(Investigative Ophthalmology and Visual Science. 1969;8:150-155.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

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Sodium-Potassium Dependent Inorganic 35S-Sulfate Incorporation into Cornea

BERNARD WORTMAN 1 and RAYMOND K. LOCKE 1

1 Bureau of Science, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D. C.

Cornea requires the presence of sodium and potassium ions in the medium for in vitro incorporation of inorganic 35S-sulfate. The effects of other cations and chemical inhibitors of Na+-K+ activated ATPase are also demonstrated. The possible role of Na+-K+ activated ATPase, of sulfate transport, and of protein-polysaccharide interactions is discussed with relation to corneal physiology.

Key Words: corneal hydration • corneal swelling • active biological transport • sulfate ions • sodium • potassium • mucopolysaccharides • ouabain • chlorpromazine • pharmacodynamics






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