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(Investigative Ophthalmology and Visual Science. 1969;8:196-200.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

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Modification of the Ocular Immune Response

I. Use of Antilymphocytic Serum to Prevent Immune Rejection of Penetrating Corneal Homografts

STEPHEN R. WALTMAN 1, H. WADE FAULKNER 1, and RONALD M. RURDE 1

1 Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine St. Louis, Mo.

Reprint requests: 517 S. Euclid Avenue, St. Louis, Mo. 63110.

Homograft penetrating corneal transplants were performed in albino rabbits. The animals were subsequently exposed to an additional antigenic stimulus from the donor animal to achieoe a uniformly high graft rejection rate. The use of systemic antilymphocyte serum completely inhibited the rejection phenomenon

Key Words: penetrating corneal transplants • graft rejection suppression • skin grafts • antigenic stimulus • corneal edema • corneal vascularization • corneal opacity




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R. M. Burde, S. R. Waltman, and J. H. Berrios
Homograft Rejection Delayed by Treatment of Donor Tissue in vitro with Antilymphocyte Serum
Science, September 3, 1971; 173(4000): 921 - 923.
[Abstract] [PDF]


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Copyright © 1969 by the Association for Research in Vision and Ophthalmology