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(Investigative Ophthalmology and Visual Science. 1969;8:475-483.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

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Histochemistry of Corneal Macular Dystrophy

ALEC GAENER 1

1 Department of Pathology, Institute of Ophthalmology, University of London, London, England

Histochemical investigation of 22 corneal discs removed from patients with hereditary macular dystrophy has revealed two types of lesion. One is granulated and lies within and around stromal keratocytes as well as in the endothelium, and is apparently composed of keratan sulfate and a hexose- or deoxyhexose-rich acidic mucosubstance. The other is intralamellar and probably consists of a similar periodate-reactive acidic polysaccharide but without appreciable keratan sulfate.

Key Words: hereditary macular dystrophy of cornea • corneal deposits • keratan sulfate • polysaccharides • histopathology • histochemistry

Submitted on February 21, 1969
Accepted on April 2, 1969




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