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(Investigative Ophthalmology and Visual Science. 1969;8:542-544.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

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Effect of Alloxan Diabetes on the Fatty Acid Composition of the Retina

SIDNEY FUTTERMAN 1, RONALD STURTEVANT 1, and CARL KUPFER 1

1 Department of Ophthalmology, University of Washington Medical School, Seattle, Wash. 98105

The fatty acid composition of untreated alloxan-diabetic and normal rat retinal tissue was compared and the relative abundance of endothelial and mural cells in the retinal capillaries was estimated. Arachidonate and docosahexaenoate were decreased in diabetic retinal tissue; linoleate was increased. The changes observed indicate that insulin is required to maintain a normal rate of polyenoic fatty acid synthesis in retinal tissue. No selective loss of mural cells from the retinal capillaries could be found.

Key Words: diabetes mellitus • alloxan • retinal capillaries • biosynthesis arachidonic acid • linoleic acid • docosahexaenoic acid • insulin






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