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(Investigative Ophthalmology and Visual Science. 1969;8:583-587.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

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The ocular immune response

III. Effect of antilymphocyte serum on the development of immunogenic uveitis

RONALD M. BURDE 1 and STEPHEN WALTMAN 1

1 Department of Ophthalmology, Washington University School of Medicine St. Louis, Mo. 63110

Rabbits receiving an intravitreal injection of egg albumin developed immunogenic uveitis spontaneously in approximately one week. Pretreatment with systemic horse antirabbit lymphocyte serum (HARLS) was highly effective in preventing the development of the uveitis. Pretreatment with normal horse serum had no effect on the uveitis. Pretreatment with HARLS also prevented sensitization of the animal to the egg albumin as the recurrent uveitis which accompanies a later intravenous challenge of the prestimidated animal did not occur. Treatment with HARLS could not prevent the secondary response after the animal had been previously sensitized.

Key Words: Antilymphocyte serum • second set responses • immunogenic uveitis • allergic uveitis • immune reaction suppression • horse serum • intramuscular injections • intravenous injections • hypersensitivity • albumin • intravitreal injection • histopathology • rabbits

Submitted on April 10, 1969
Accepted on May 20, 1969




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[Abstract] [Full Text] [PDF]


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