IOVS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

(Investigative Ophthalmology and Visual Science. 1969;8:595-604.)
© 1969 by The Association for Research in Vision and Ophthalmology, Inc.

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HERRON, W. L.
Right arrow Articles by RUBIN, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HERRON, W. L.
Right arrow Articles by RUBIN, M. L.

Retinal dystrophy in the rat-A pigment epithelial disease

WARREN L. HERRON 1, BYRON W. RIEGEL 1, ORLO E. MYERS 1, and MELVIN L. RUBIN 1

1 Department of Ophthalmology, University of Florida College of Medicine Gainesville, Fla.

Rod outer segment renewal rate was studied by autoradiographic technique in both the Wistar rat (control) and the Royal College of Surgeons (RCS) dystrophic rat. The dystrophic rat showed normal renewal rate until age 18 days, whereupon further outer segment disc movement slowed and a previously established retrograde degeneration of outer segments progressed. The dystrophic rat differed from the normal in that it showed no evidence of phagocytosis of rod outer segment material by its pigment epithelium. Argument that the primary retinal defect is at the level of the pigment epithelium is presented.

Key Words: retinal dystrophy • heredity • pathogenesis • retinal pigment epithelium • phagocytosis • retinal rod outer segment • retinitis pigmentosa • methionine • tritium • histopathology • rats • Royal College of Surgeons • retinal degeneration

Submitted on July 10, 1969
Accepted on August 11, 1969




This article has been cited by other articles:


Home page
 Br. J. Ophthalmol.Home page
A J Brea-Fernandez, E Pomares, M J Brion, G Marfany, M J Blanco, M Sanchez-Salorio, R Gonzalez-Duarte, and A Carracedo
Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa
Br. J. Ophthalmol., October 1, 2008; 92(10): 1419 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
L. Mecklenburg and U. Schraermeyer
An Overview on the Toxic Morphological Changes in the Retinal Pigment Epithelium after Systemic Compound Administration
Toxicol Pathol, February 1, 2007; 35(2): 252 - 267.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. L. Duncan, M. M. LaVail, D. Yasumura, M. T. Matthes, H. Yang, N. Trautmann, A. V. Chappelow, W. Feng, H. S. Earp, G. K. Matsushima, et al.
An RCS-Like Retinal Dystrophy Phenotype in Mer Knockout Mice
Invest. Ophthalmol. Vis. Sci., February 1, 2003; 44(2): 826 - 838.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
P. M. D'Cruz, D. Yasumura, J. Weir, M. T. Matthes, H. Abderrahim, M. M. LaVail, and D. Vollrath
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
Hum. Mol. Genet., March 1, 2000; 9(4): 645 - 651.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
J. M. Lawrence, Y. Sauvé, D. J. Keegan, P. J. Coffey, L. Hetherington, S. Girman, S. J. O. Whiteley, A. S. L. Kwan, T. Pheby, and R. D. Lund
Schwann Cell Grafting into the Retina of the Dystrophic RCS Rat Limits Functional Deterioration
Invest. Ophthalmol. Vis. Sci., February 1, 2000; 41(2): 518 - 528.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
S. Mergler, K. Steinhausen, M. Wiederholt, and O. Strauss
Altered regulation of L-type channels by protein kinase C and protein tyrosine kinases as a pathophysiologic effect in retinal degeneration
FASEB J, September 1, 1998; 12(12): 1125 - 1134.
[Abstract] [Full Text]

Home page
 ScienceHome page
R. Frank, R. Keirn, G. Keirn, M. Mancini, and J. Khoury
Retinal dystrophy: development retarded by galactose feeding in spontaneously hypertensive rats
Science, January 24, 1986; 231(4736): 376 - 378.
[Abstract] [PDF]

Home page
 ScienceHome page
A. Goldman and P. O'Brien
Phagocytosis in the retinal pigment epithelium of the RCS rat
Science, September 15, 1978; 201(4360): 1023 - 1025.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Edwards and R. Szamier
Defective phagocytosis of isolated rod outer segments by RCS rat retinal pigment epithelium in culture
Science, September 2, 1977; 197(4307): 1001 - 1003.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Mullen and M. LaVail
Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras
Science, May 21, 1976; 192(4241): 799 - 801.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Vollrath, W. Feng, J. L. Duncan, D. Yasumura, P. M. D'Cruz, A. Chappelow, M. T. Matthes, M. A. Kay, and M. M. LaVail
Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk
PNAS, October 23, 2001; 98(22): 12584 - 12589.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1969 by the Association for Research in Vision and Ophthalmology