Erratum
for
Hart et al., Invest. Ophthalmol. Vis. Sci. 46 (9) 3443-3450.
(Investigative Ophthalmology and Visual Science. 2006;47:5170.)
© 2006 by The Association for Research in Vision and Ophthalmology, Inc.
ERRATUM
Erratum in: "Genotype-Phenotype Correlation of Mouse Pde6b Mutations" by Hart et al. (Invest Ophthalmol Vis Sci. 2005;46:3443–3450).
The numbering for the atrd3 mutation given is incorrect. The atrd3 point mutation in Pde6b is A1814G causing N605S and not A1817G causing N606S as stated in the paper. In Table 1 the entry for atrd3 in the DNA Change column should read A1814G and the entry in the Protein Change column should read Asn605Ser. In Figure 1 the label for the atrd3 mutation should read "N605S" and the accompanying arrow should point to N605.
Under Discussion, paragraph 2, the second sentence should read, "Two have missense mutations (His620Gln and Asn605Ser) and the third a 5' splice site mutation (IVS11+5G
A)." The seventh sentence should read, "The only other missense mutation, Pde6batrd3 is Asn605Ser, situated nearby in the putative catalytic domain, and is more detrimental to protein function based on the phenotype analysis." The ninth sentence should read, "The affected asparagine residue is highly conserved in mammalian phosphodiesterases (Fig. 1 ), and the phenotypic consequence of the substitution indicates the importance of this residue in protein function."
In paragraph 3, the eighth sentence should read, "The impact on protein function of the Asn605Ser mutation in atrd3 is less readily assessable."
