IOVS Journal of Applied Physiology
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Originally published In Press as doi:10.1167/iovs.07-1320 on April 25, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:3529-3534.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.07-1320
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Differential Optical Densities of Intraretinal Spaces

Daniel Barthelmes,1,2 Florian K. P. Sutter,3 and Mark C. Gillies4

1From the Departments of Ophthalmology and 2Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland; the 3Department of Ophthalmology, University Hospital Zürich, Zürich, Switzerland; and the 4Save Sight Institute, Department of Clinical Ophthalmology and Eye Health, University of Sydney, Sydney, Australia.

PURPOSE. To test the hypothesis that hyporeflective spaces in the neuroretina found on optical coherence tomography (OCT) examination have different optical reflectivities according to whether they are associated with exudation or degeneration.

METHODS. Retrospective analysis of eyes with idiopathic perifoveal telangiectasia (IPT), diabetic macular edema (DME), idiopathic central serous chorioretinopathy (CSC), retinitis pigmentosa (RP), or cone dystrophy (CD) and eyes of healthy control subjects. OCT scans were performed. Raw scan data were exported and used to calculate light reflectivity profiles. Reflectivity data were acquired by projecting three rectangular boxes, each 50 pixels long and 5 pixels wide, into the intraretinal cystoid spaces, centrally onto unaffected peripheral RPE, and onto the prefoveolar vitreous. Light reflectivity in the retinal pigment epithelium (RPE), vitreous, and intraretinal spaces for the different retinal conditions and control subjects were compared.

RESULTS. Reflectivities of the vitreous and the RPE were similar among the groups. Hyporeflective spaces in eyes with exudation (DME, RP, and CSC) had higher reflectivity compared with the mean reflectivity of the vitreous, whereas the cystoid spaces in the maculae of the eyes without exudation (CD and IPT) had a lower reflectivity than did the normal vitreous.

CONCLUSIONS. Analysis of the light reflectivity profiles may be a tool to determine whether the density of hyporeflective spaces in the macula is greater or less than that of the vitreous, and may be a way to differentiate degenerative from exudative macular disease.






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