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Originally published In Press as doi:10.1167/iovs.08-2003 on April 25, 2008
 (Investigative Ophthalmology and Visual Science. 2008;49:3617-3621.)
© 2008 by The Association for Research in Vision and Ophthalmology, Inc.
DOI:  10.1167/iovs.08-2003
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A New Method to Monitor Visual Field Defects Caused by Photoreceptor Degeneration by Quantitative Optical Coherence Tomography

M. Dominik Fischer,1 Johannes C. Fleischhauer,2 Mark C. Gillies,3 Florian K. Sutter,4 Horst Helbig,5 and Daniel Barthelmes2

1From the Institute for Ophthalmic Research, University Eye Hospital, Tübingen, Germany; the 2Department of Ophthalmology, University Hospital, Inselspital, Bern, Switzerland; the 3Save Sight Institute, University of Sydney, Sydney, Australia; the 4Department of Ophthalmology, University Hospital, Zurich, Switzerland; and the 5Department of Ophthalmology, University Hospital, Regensburg, Germany.

PURPOSE. To correlate the dimension of the visual field (VF) tested by Goldman kinetic perimetry with the extent of visibility of the highly reflective layer between inner and outer segments of photoreceptors (IOS) seen in optical coherence tomography (OCT) images in patients with retinitis pigmentosa (RP).

METHODS. In a retrospectively designed cross-sectional study, 18 eyes of 18 patients with RP were examined with OCT and Goldmann perimetry using test target I4e and compared with 18 eyes of 18 control subjects. A-scans of raw scan data of Stratus OCT images (Carl Zeiss Meditec, AG, Oberkochen, Germany) were quantitatively analyzed for the presence of the signal generated by the highly reflective layer between the IOS in OCT images. Starting in the fovea, the distance to which this signal was detectable was measured. Visual fields were analyzed by measuring the distance from the center point to isopter I4e. OCT and visual field data were analyzed in a clockwise fashion every 30°, and corresponding measures were correlated.

RESULTS. In corresponding alignments, the distance from the center point to isopter I4e and the distance to which the highly reflective signal from the IOS can be detected correlate significantly (r = 0.75, P < 0.0001). The greater the distance in VF, the greater the distance measured in OCT.

CONCLUSIONS. The authors hypothesize that the retinal structure from which the highly reflective layer between the IOS emanates is of critical importance for visual and photoreceptor function. Further research is warranted to determine whether this may be useful as an objective marker of progression of retinal degeneration in patients with RP.






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