About the Cover
Cover: High resolution, digital, 3D reconstruction of the optic nerve head (ONH) and peripapillary scleral connective tissues of a normal monkey eye perfusion fixed at an IOP of 10 mm Hg. In this reconstruction, the principal connective tissue structures have been delineated within 323 serial section images of the stained, embedded tissue block surface acquired after 3 micrometer sections are cut away. Reconstructions of the normal and early glaucomatous eyes of three monkeys demonstrate that at the earliest stage of glaucomatous damage, the connective tissues of the lamina cribrosa and neural canal wall are profoundly and permanently altered. Finite element models based on 3D reconstructions such as these may eventually lead to a science for predicting the susceptibility of an individual ONH's neural and connective tissues to a given level of IOP. Please see Burgoyne et al. on page 4388 of this issue.
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Copyright © 2004 by the Association for Research in Vision and Ophthalmology
