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Cover: Expression of MMP-14 (green) in the transacted rat optic nerve primed for regeneration by injection of chicken neural tube-derived stem cells. MMP-14 expression colocalizes with GFAP-positive cells (red). MMP-14 plays an important role in the regeneration of the optic nerve by activating MMP-2, which digests CSPG, a regeneration inhibiting molecule of the extracellular matrix of the CNS. See Charalambous et al. on page 3513 of this issue.