Genetics

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Glaucoma December 2023

MiR-29b Downregulation by p53/Sp1 Complex Plays a Critical Role in Bleb Scar Formation After Glaucoma Filtration Surgery

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Ning Li; Zixi Wang; Fan Yang; Wenjun Hu; Xiaojun Zha; Xuanchu Duan
TAGS: blister, cicatrix, filtering surgery, glaucoma, down-regulation, plicamycin, marfan syndrome, myxofibrosarcoma of skin
Trans. Vis. Sci. Tech.. 2023; 12(12):5. https://doi.org/10.1167/tvst.12.12.5

Glaucoma December 2023

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells

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Tilahun Ayane Debele; Zachary F. Mount; Yong Yuan; Winston W.-Y. Kao; Yoonjee C. Park
TAGS: actins, collagen, cytotoxicity, dexamethasone, gel, glaucoma, permeability, phenotype, prevention, trabecular meshwork
Trans. Vis. Sci. Tech.. 2023; 12(12):4. https://doi.org/10.1167/tvst.12.12.4

Includes: Supplemental Content

Lens December 2023

HO-1–Mediated Autophagic Restoration Protects Lens Epithelial Cells Against Oxidative Stress and Cellular Senescence

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Lijun Wang; Wei Lou; Yao Zhang; Ziang Chen; Yang Huang; Haiying Jin
TAGS: autophagy, cellular senescence, hydrogen peroxide, lens epithelial cell, lens, crystalline, oxidative stress, aging, older adult, mice, cyclophosphamide/prednisone/procarbazine/vincristine
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):6. https://doi.org/10.1167/iovs.64.15.6

Includes: Supplemental Content

Immunology and Microbiology November 2023

Too Much of a Good Thing: Extended Duration of Gut Microbiota Depletion Reverses Protection From Experimental Autoimmune Uveitis

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Ryan Salvador; Reiko Horai; Amy Zhang; Yingyos Jittayasothorn; Jihong Tang; Akriti Gupta; Vijayaraj Nagarajan; Rachel R. Caspi
TAGS: antibiotics, autoimmunity, mice, microbiome, uveitis, genes, rna, ribosomal, 16s, t-lymphocytes, immunization
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):43. https://doi.org/10.1167/iovs.64.14.43

Retina November 2023

GSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3/MLKL-Mediated RGC Necroptosis After Ischemia/Reperfusion

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Yanlin Feng; Chenyang Hu; Kaixuan Cui; Matthew Fan; Wu Xiang; Dan Ye; Yuxun Shi; Huiwen Ye; Xue Bai; Yantao Wei; Yue Xu; Jingjing Huang
TAGS: ischemia, necroptosis, reperfusion therapy, wounds and injuries, physiologic reperfusion, retina
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):42. https://doi.org/10.1167/iovs.64.14.42

Includes: Supplemental Content

Visual Neuroscience November 2023

Altered Perception of the Bistable Motion Quartet in Albinism

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Khaldoon O. Al-Nosairy; Elisabeth V. Quanz; Charlotta M. Eick; Michael B. Hoffmann; Jürgen Kornmeier
TAGS: albinism, motion, motion perception, perception, pathologic nystagmus
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):39. https://doi.org/10.1167/iovs.64.14.39

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2023

Time Spent Outdoors Partly Accounts for the Effect of Education on Myopia

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Rosie Clark; Sander C. M. Kneepkens; Denis Plotnikov; Rupal L. Shah; Yu Huang; J. Willem L. Tideman; Caroline C. W. Klaver; Denize Atan; Cathy Williams; Jeremy A. Guggenheim; for the UK Biobank Eye and Vision Consortium
TAGS: child, genome-wide association study, knowledge acquisition, mendelian randomization analysis, myopia, refractive errors, biobanks, adult
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):38. https://doi.org/10.1167/iovs.64.14.38

Includes: Supplemental Content

Retina November 2023

A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells

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Eric C. Spivey; Jinggang Yin; Edward Chaum; John P. Wikswo
TAGS: retinal pigment cell, vascular endothelial growth factor a, fluid flow, bodily secretions, hypoxia
Trans. Vis. Sci. Tech.. 2023; 12(11):28. https://doi.org/10.1167/tvst.12.11.28

Includes: Supplemental Content

Genetics November 2023

Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals

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Perttu J. Liuska; Joel T. Rämö; Susanna Lemmelä; Kai Kaarniranta; Hannu Uusitalo; Elisa Lahtela; Mark J. Daly; Mika Harju; Aarno Palotie; Joni A. Turunen; for the FinnGen Study†
TAGS: apolipoprotein e, eye diseases, glaucoma, haplotypes, apolipoprotein e genotype, alleles, genotype
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):33. https://doi.org/10.1167/iovs.64.14.33

Includes: Supplemental Content

Retina November 2023

Deep Learning–Facilitated Study of the Rate of Change in Photoreceptor Outer Segment Metrics in RPGR -Related X-Linked Retinitis Pigmentosa

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Yi-Zhong Wang; Katherine Juroch; Yineng Chen; Gui-Shuang Ying; David G. Birch
TAGS: deep learning, photoreceptors, retinitis pigmentosa, volume, x-linked inheritance, eye, baseline value, follow-up, disease progression
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):31. https://doi.org/10.1167/iovs.64.14.31

Physiology and Pharmacology November 2023

O-GlcNAcylation Inhibition Upregulates Connexin43 Expression in the Endothelium to Protect the Tight Junction Barrier in Diabetic Retinopathy

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Guodong Liu; Le Feng; Xiaoqiang Liu; Peng Gao; Fang Wang
TAGS: connexin 43, tight junctions, glucose, diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):30. https://doi.org/10.1167/iovs.64.14.30

Includes: Supplemental Content

Clinical and Epidemiologic Research November 2023

Changes in Refractive Error During Young Adulthood: The Effects of Longitudinal Screen Time, Ocular Sun Exposure, and Genetic Predisposition

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Samantha Sze-Yee Lee; Gareth Lingham; Carol A. Wang; Santiago Diaz Torres; Craig E. Pennell; Pirro G. Hysi; Christopher J. Hammond; Puya Gharahkhani; Rosie Clark; Jeremy A. Guggenheim; David A. Mackey
TAGS: adult, genetic predisposition to disease, myopia, refractive errors, screen time, sun exposure
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):28. https://doi.org/10.1167/iovs.64.14.28

Includes: Supplemental Content

Anatomy and Pathology/Oncology November 2023

Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation

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Jay Jiyong Kwak; Kwang Seob Lee; Junwon Lee; Yong Joon Kim; Eun Young Choi; Suk Ho Byeon; Won Seok Chang; Yu Ri Kim; Jin Seok Kim; Saeam Shin; Seung-Tae Lee; Sung Soo Kim; Christopher Seungkyu Lee
TAGS: biopsy, massively-parallel genome sequencing, primary vitreoretinal lymphoma, vitreous body, liquid biopsy, genotype-phenotype associations
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):27. https://doi.org/10.1167/iovs.64.14.27

Includes: Supplemental Content

Genetics November 2023

Clinical Characteristics and Genetic Variants in Taiwanese Patients With PROM1 -Related Inherited Retinal Disorders

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Tzu-Yi Lin; Pei-Liang Wu; Eugene Yu-Chuan Kang; Yi-Chun Chi; Laura A. Jenny; Pei-Hsuan Lin; Chia-Ying Lee; Chun-Hsiu Liu; Laura Liu; Lung-Kun Yeh; Kuan-Jen Chen; Yih-Shiou Hwang; Wei-Chi Wu; Chi-Chun Lai; Meng-Chang Hsiao; Pei-Kang Liu; Nan-Kai Wang
TAGS: electroretinography, genetics, retinal diseases, spectral domain-optical coherence tomography, taiwanese, fundus autofluorescence imaging, color, family, genes
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):25. https://doi.org/10.1167/iovs.64.14.25

Includes: Supplemental Content

Genetics November 2023

Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration

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Ilhan E. Acar; Tessel E. Galesloot; Ulrich F. O. Luhmann; Sascha Fauser; Javier Gayán; Anneke I. den Hollander; Everson Nogoceke
TAGS: age-related macular degeneration, genes, genome, whole genome sequencing, asthma
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):24. https://doi.org/10.1167/iovs.64.14.24

Includes: Supplemental Content

Glaucoma November 2023

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone

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Xiaofeng Zhu; Bei Zeng; Caiqing Wu; Zidong Chen; Minbin Yu; Yangfan Yang
TAGS: fibrosis, intraocular pressure, mice, pirfenidone, trabecular meshwork, western blotting, cytoskeleton
Trans. Vis. Sci. Tech.. 2023; 12(11):21. https://doi.org/10.1167/tvst.12.11.21

Cornea November 2023

Endoplasmic Reticulum Stress Disrupts Mitochondrial Bioenergetics, Dynamics and Causes Corneal Endothelial Cell Apoptosis

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Saba Qureshi; Stephanie Lee; William Steidl; Lukas Ritzer; Michael Parise; Ananya Chaubal; Varun Kumar
TAGS: apoptosis, bioenergetics, cornea, endothelial cells, mitochondria, stress, tunicamycin, endoplasmic reticulum, proteins, corneal endothelium
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):18. https://doi.org/10.1167/iovs.64.14.18

Includes: Supplemental Content

Retina November 2023

Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers

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Gabriel Velez; Julian Wolf; Antoine Dufour; Prithvi Mruthyunjaya; Vinit B. Mahajan
TAGS: biological markers, intraocular melanoma, neoplasms, proteins, proteomics, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):14. https://doi.org/10.1167/iovs.64.14.14

Includes: Supplemental Content

Cornea November 2023

Diabetes-Associated Hyperglycemia Causes Rapid-Onset Ocular Surface Damage

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Judy Weng; Christopher Ross; Jacob Baker; Saleh Alfuraih; Kiumars Shamloo; Ajay Sharma
TAGS: diabetes mellitus, diabetes mellitus, type 2, hyperglycemia, ocular surfaces, mice, cornea, goblet cells, glycocalyx, tear film finding
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):11. https://doi.org/10.1167/iovs.64.14.11

Genetics November 2023

Corneal Vascularization Associated With a Novel PDGFRB Variant

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Titas Gladkauskas; Ove Bruland; Leen Abu Safieh; Deepak P. Edward; Eyvind Rødahl; Cecilie Bredrup
TAGS: corneal neovascularization, genes, ligands, platelet-derived growth factor beta receptor, platelet-derived growth factor, protein-tyrosine kinase inhibitor, glucose
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):9. https://doi.org/10.1167/iovs.64.14.9

Includes: Supplemental Content

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MiR-29b Downregulation by p53/Sp1 Complex Plays a Critical Role in Bleb Scar Formation After Glaucoma Filtration Surgery

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells

HO-1–Mediated Autophagic Restoration Protects Lens Epithelial Cells Against Oxidative Stress and Cellular Senescence

Too Much of a Good Thing: Extended Duration of Gut Microbiota Depletion Reverses Protection From Experimental Autoimmune Uveitis

GSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3/MLKL-Mediated RGC Necroptosis After Ischemia/Reperfusion

Altered Perception of the Bistable Motion Quartet in Albinism

Time Spent Outdoors Partly Accounts for the Effect of Education on Myopia

A Microfluidic Platform for the Time-Resolved Interrogation of Polarized Retinal Pigment Epithelial Cells

Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals

Deep Learning–Facilitated Study of the Rate of Change in Photoreceptor Outer Segment Metrics in RPGR -Related X-Linked Retinitis Pigmentosa

O-GlcNAcylation Inhibition Upregulates Connexin43 Expression in the Endothelium to Protect the Tight Junction Barrier in Diabetic Retinopathy

Changes in Refractive Error During Young Adulthood: The Effects of Longitudinal Screen Time, Ocular Sun Exposure, and Genetic Predisposition

Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation

Clinical Characteristics and Genetic Variants in Taiwanese Patients With PROM1 -Related Inherited Retinal Disorders

Whole Genome Sequencing Identifies Novel Common and Low-Frequency Variants Associated With Age-Related Macular Degeneration

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone

Endoplasmic Reticulum Stress Disrupts Mitochondrial Bioenergetics, Dynamics and Causes Corneal Endothelial Cell Apoptosis

Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers

Diabetes-Associated Hyperglycemia Causes Rapid-Onset Ocular Surface Damage

Corneal Vascularization Associated With a Novel PDGFRB Variant

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