Genetics

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Anatomy and Pathology/Oncology June 2023

In Vitro Testing of the Virus-Like Drug Conjugate Belzupacap Sarotalocan (AU-011) on Uveal Melanoma Suggests BAP1-Related Immunostimulatory Capacity

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Sen Ma; Ruben V. Huis In't Veld; Alexander Houy; Marc-Henri Stern; Cadmus Rich; Ferry A. Ossendorp; Martine J. Jager
TAGS: bap1 gene, cell lines, drug conjugates, hsp90 heat-shock proteins, intraocular melanoma, viruses, cytotoxicity, cell death
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):10. doi: https://doi.org/10.1167/iovs.64.7.10

Includes: Supplemental Content

Genetics June 2023

Associations of VEGF Polymorphisms With Retinopathy of Prematurity

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Xiao Chun Ling; Eugene Yu-Chuan Kang; Kuan-Jen Chen; Nan-Kai Wang; Laura Liu; Yen-Po Chen; Yih-Shiou Hwang; Chi-Chun Lai; Shun-Fa Yang; Wei-Chi Wu
TAGS: polymorphism, retinopathy of prematurity, vascular endothelial growth factor a, infant
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):11. doi: https://doi.org/10.1167/iovs.64.7.11

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2023

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

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Yanyan Xie; Yuan Pan; Qian Chen; Yuxi Chen; Guanyu Chen; Mei Wang; Peng Zeng; Zhuang Li; Zuoyi Li; Sha Wang; Huasheng Yang; Dan Liang
TAGS: fibrosis, forkhead box protein m1, graves' ophthalmopathy, fibroblasts, proteins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):9. doi: https://doi.org/10.1167/iovs.64.7.9

Includes: Supplemental Content

Genetics June 2023

Association of Polymorphisms in ZFHX1B and PAX6 With Anisometropia in Chinese Children: The Hong Kong Children Eye Genetics Study

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Yu Yao Wang; Xiu Juan Zhang; Ka Wai Kam; Zhen Ji Chen; Yuzhou Zhang; Fang Yao Tang; Fen Fen Li; Pancy O. S. Tam; Wilson W. K. Yip; Alvin L. Young; Clement C. Tham; Chi Pui Pang; Jason C. Yam; Li Jia Chen
TAGS: anisometropia, child, chinese (other dialects), eye, pax6 transcription factor, single nucleotide polymorphism, genetics, hong kong, chinese people, polymorphism
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):6. doi: https://doi.org/10.1167/iovs.64.7.6

Includes: Supplemental Content

Retina June 2023

Low-Dose Trans -Resveratrol Ameliorates Diabetes-Induced Retinal Ganglion Cell Degeneration via TyrRS/c-Jun Pathway

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Ke Xiao; Xiao-Hong Ma; Zheng Zhong; Yin Zhao; Xu-Hui Chen; Xu-Fang Sun
TAGS: diabetes mellitus, ganglia, resveratrol, retinal ganglion cells, tissue degeneration, western blotting, nuclear translocation, apoptosis, phosphorylation
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):2. doi: https://doi.org/10.1167/iovs.64.7.2

Includes: Supplemental Content

Article June 2023

Statistical image properties and aesthetic judgments on abstract paintings by Robert Pepperell

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Christoph Redies; Ralf Bartho
TAGS: esthetics, judgment, paintings, heterogeneity of variance
Journal of Vision. 2023; 23(6):1. doi: https://doi.org/10.1167/jov.23.6.1

Includes: Supplemental Content

Cornea May 2023

Z nf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome

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Jing Bao; Xiaoning Yu; Xiyuan Ping; Xingchao Shentu; Jian Zou
TAGS: cornea, ehlers-danlos syndrome 6b, mutation, zebrafish, regulation, larva
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):29. doi: https://doi.org/10.1167/iovs.64.5.29

Includes: Supplemental Content

Retina May 2023

Identification of Five Novel Variants in the TSPAN12 Gene in Chinese Families With Familial Exudative Vitreoretinopathy

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You Wang; Qiong Wang; Songshan Li; Xiaoyan Ding
TAGS: chinese (other dialects), chinese people, familial exudative vitreoretinopathies, family, genes, luciferases
Trans. Vis. Sci. Tech.. 2023; 12(5):29. doi: https://doi.org/10.1167/tvst.12.5.29

Cornea May 2023

Norepinephrine as the Intrinsic Contributor to Contact Lens–Induced Pseudomonas aeruginosa Keratitis

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Bi Ning Zhang; Benxiang Qi; Wai Kit Chu; Fangying Song; Suxia Li; Qiaoqiao Dong; Zheng Shao; Bin Zhang; Xianli Du; Xiubin Ma; Vishal Jhanji; Qingjun Zhou
TAGS: adrb2 gene, beta-2 adrenergic receptors, contact lenses, cornea, infections, keratitis, mice, norepinephrine, pseudomonas aeruginosa, epithelium
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):26. doi: https://doi.org/10.1167/iovs.64.5.26

Includes: Supplemental Content

Immunology and Microbiology May 2023

Identification of Hif1α as a Potential Participant in Autoimmune Uveitis Pathogenesis Using Single-Cell Transcriptome Analysis

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Lei Zhu; He Li; Rong Wang; Zhaohuai Li; Sichen Zhao; Xuening Peng; Wenru Su
TAGS: autoimmunity, mice, pathogenesis, regulatory t-lymphocytes, single-cell gene expression analysis, t-lymphocytes, uveitis, transcription, genetic, flow cytometry, rna, small cytoplasmic
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):24. doi: https://doi.org/10.1167/iovs.64.5.24

Includes: Supplemental Content

Letters to the Editor May 2023

Letter to the Editor: Characterization of Choriocapillaris and Choroidal Abnormalities in Alport Syndrome

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Damir Bosnar; Mira Knežić Zagorec; Mladen Bušić; Valentina Cigić; Nikola Zagorec; Tamara Nikuševa Martić; Danica Galešić Ljubanović
TAGS: hereditary nephritis
Trans. Vis. Sci. Tech.. 2023; 12(5):25. doi: https://doi.org/10.1167/tvst.12.5.25

Article May 2023

Increments in visual motion coherence are more readily detected than decrements

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Lai Wei; Autumn O. Mitchell; John H. R. Maunsell
TAGS: motion, neurons
Journal of Vision. 2023; 23(5):18. doi: https://doi.org/10.1167/jov.23.5.18

Includes: Supplemental Content

Lens May 2023

System for Objective Assessment of the Accommodation Response During Subjective Refraction

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Carlos E. García-Guerra; Joan A. Martínez-Roda; Juan C. Ondategui-Parra; Aina Turull-Mallofré; Mikel Aldaba; Meritxell Vilaseca
TAGS: lens (device), refraction, visual accommodation, eye, lens, crystalline
Trans. Vis. Sci. Tech.. 2023; 12(5):22. doi: https://doi.org/10.1167/tvst.12.5.22

Physiology and Pharmacology May 2023

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization

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Nan Shu; Zhi Zhang; Xiaotang Wang; Ruonan Li; Wanqian Li; Xianyang Liu; Qi Zhang; Zhengxuan Jiang; Liming Tao; Li Zhang; Shengping Hou
TAGS: autoimmunity, microglia, uveitis, toll-like receptor 4, western blotting, myd88 gene, proteins, inflammation
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):21. doi: https://doi.org/10.1167/iovs.64.5.21

Includes: Supplemental Content

Cornea May 2023

The TCF4 Trinucleotide Repeat Expansion of Fuchs’ Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye

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Jiaxin Hu; Xin Gong; Samantha T. Johnson; David R. Corey; V. Vinod Mootha
TAGS: body tissue, cornea, corneal endothelium, corneal stroma, endothelium, eye, hereditary corneal dystrophy, rna, trabecular meshwork, trinucleotide repeat expansion
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):16. doi: https://doi.org/10.1167/iovs.64.5.16

Includes: Supplemental Content

Retinal Cell Biology May 2023

Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies

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Gabriel E. Bertolesi; Maxwell F. J. Chilije; Victoria Li; Chase C. Thompson; Arturo López-Villalobos; Carrie L. Hehr; Karen Atkinson-Leadbeater; Vanina Zaremberg; Sarah McFarlane
TAGS: acyltransferase, eye, lipids, proteins, xenopus, embryo, yeasts, enzymes, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):17. doi: https://doi.org/10.1167/iovs.64.5.17

Includes: Supplemental Content

Cornea May 2023

The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression

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Sébastien Méthot; Stéphanie Proulx; Isabelle Brunette; Patrick J. Rochette
TAGS: disease progression, endothelium, hereditary corneal dystrophy, mitochondria, chronic exertional compartment syndrome, calcium
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):13. doi: https://doi.org/10.1167/iovs.64.5.13

Includes: Supplemental Content

Immunology and Microbiology May 2023

Metagenomic Sequencing Analysis Identifies Cross-Cohort Gut Microbial Signatures Associated With Age-Related Macular Degeneration

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Wei Xue; Peiyao Peng; Xiaofeng Wen; Huan Meng; Yali Qin; Tingting Deng; Shixin Guo; Tingting Chen; Xifang Li; Juanran Liang; Feng Zhang; Zhi Xie; Ming Jin; Qiaoxing Liang; Lai Wei
TAGS: age-related macular degeneration, cohort studies, datasets, dysbiosis, microbiome, chinese (other dialects), bacteriophages, chinese people
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):11. doi: https://doi.org/10.1167/iovs.64.5.11

Includes: Supplemental Content

Retina May 2023

Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Proliferative Vitreoretinopathy

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Edward F. Xie; Bingqing Xie; Urooba Nadeem; Mark D'Souza; Gonnah Reem; Dinanath Sulakhe; Dimitra Skondra
TAGS: bioinformatics, genes, vitreoretinopathy, proliferative
Trans. Vis. Sci. Tech.. 2023; 12(5):19. doi: https://doi.org/10.1167/tvst.12.5.19

Includes: Supplemental Content

Genetics May 2023

Familial Whole Exome Sequencing Study of 30 Families With Early-Onset High Myopia

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Entuan Yang; Jifeng Yu; Xue Liu; Huihui Chu; Li Li
TAGS: candidate disease gene, family, myopia, proband, whole exome sequencing, genes, mutation
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):10. doi: https://doi.org/10.1167/iovs.64.5.10

Includes: Supplemental Content

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In Vitro Testing of the Virus-Like Drug Conjugate Belzupacap Sarotalocan (AU-011) on Uveal Melanoma Suggests BAP1-Related Immunostimulatory Capacity

Associations of VEGF Polymorphisms With Retinopathy of Prematurity

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

Association of Polymorphisms in ZFHX1B and PAX6 With Anisometropia in Chinese Children: The Hong Kong Children Eye Genetics Study

Low-Dose Trans -Resveratrol Ameliorates Diabetes-Induced Retinal Ganglion Cell Degeneration via TyrRS/c-Jun Pathway

Statistical image properties and aesthetic judgments on abstract paintings by Robert Pepperell

Z nf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome

Identification of Five Novel Variants in the TSPAN12 Gene in Chinese Families With Familial Exudative Vitreoretinopathy

Norepinephrine as the Intrinsic Contributor to Contact Lens–Induced Pseudomonas aeruginosa Keratitis

Identification of Hif1α as a Potential Participant in Autoimmune Uveitis Pathogenesis Using Single-Cell Transcriptome Analysis

Letter to the Editor: Characterization of Choriocapillaris and Choroidal Abnormalities in Alport Syndrome

Increments in visual motion coherence are more readily detected than decrements

System for Objective Assessment of the Accommodation Response During Subjective Refraction

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization

The TCF4 Trinucleotide Repeat Expansion of Fuchs’ Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye

Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies

The Presence of Guttae in Fuchs Endothelial Corneal Dystrophy Explants Correlates With Cellular Markers of Disease Progression

Metagenomic Sequencing Analysis Identifies Cross-Cohort Gut Microbial Signatures Associated With Age-Related Macular Degeneration

Using Advanced Bioinformatics Tools to Identify Novel Therapeutic Candidates for Proliferative Vitreoretinopathy

Familial Whole Exome Sequencing Study of 30 Families With Early-Onset High Myopia

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