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Articles May 2022

Automated Assessment of Photoreceptor Visibility in Adaptive Optics Split-Detection Images Using Edge Detection

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Min Chen; Yu You Jiang; James C. Gee; David H. Brainard; Jessica I. W. Morgan
TAGS: optics, photoreceptors
Trans. Vis. Sci. Tech.. 2022; 11(5):25. doi: https://doi.org/10.1167/tvst.11.5.25

Includes: Supplemental Content

Genetics May 2022

Different Phenotypes Represent Advancing Stages of ABCA4 -Associated Retinopathy: A Longitudinal Study of 212 Chinese Families From a Tertiary Center

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Yingwei Wang; Wenmin Sun; Jing Zhou; Xueqing Li; Yi Jiang; Shiqiang Li; Xiaoyun Jia; Xueshan Xiao; Jiamin Ouyang; Yueye Wang; Lin Zhou; Yuxi Long; Mengchu Liu; Yongyu Li; Zhen Yi; Panfeng Wang; Qingjiong Zhang
TAGS: abca4 gene, chinese (other dialects), chinese people, longitudinal studies, phenotype, retinal diseases, family
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):28. doi: https://doi.org/10.1167/iovs.63.5.28

Includes: Supplemental Content

Genetics May 2022

Identification of a Complex Allele in IMPG2 as a Cause of Adult-Onset Vitelliform Macular Dystrophy

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Irene Vázquez-Domínguez; Catherina H. Z. Li; Zeinab Fadaie; Lonneke Haer-Wigman; Frans P. M. Cremers; Alejandro Garanto; Carel B. Hoyng; Susanne Roosing
TAGS: adult, alleles, persistent postconcussive syndrome, postpolypectomy coagulation syndrome, vitelliform dystrophy, exons, rna splicing, genes
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):27. doi: https://doi.org/10.1167/iovs.63.5.27

Includes: Supplemental Content

Articles May 2022

Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device

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Anna M. Waldie; Angharad E. Hobby; Isabelle Chow; Elisa E. Cornish; Mathura Indusegaran; Aleksandra Pekacka; Phuc Nguyen; Clare Fraser; Alison M. Binns; Miles R. Stanford; Christopher J. Hammond; Peter J. McCluskey; John R. Grigg; Omar A. Mahroo
TAGS: electroretinography, mobile devices, photopsia, vitiliginous chorioretinitis, electrophysiology
Trans. Vis. Sci. Tech.. 2022; 11(5):23. doi: https://doi.org/10.1167/tvst.11.5.23

Articles May 2022

Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration

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A. Itzam Marin; Felix Poppelaars; Brandie D. Wagner; Alan G. Palestine; Jennifer L. Patnaik; V. Michael Holers; Ashley A. Frazer-Abel; Marc T. Mathias; Niranjan Manoharan; Cheryl N. Fonteh; Naresh Mandava; Anne M. Lynch; for the University of Colorado Retina Research Group
TAGS: age-related macular degeneration, complement system proteins
Trans. Vis. Sci. Tech.. 2022; 11(5):22. doi: https://doi.org/10.1167/tvst.11.5.22

Includes: Supplemental Content

Articles May 2022

Comparison of Cone Mosaic Metrics From Images Acquired With the SPECTRALIS High Magnification Module and Adaptive Optics Scanning Light Ophthalmoscopy

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Niamh Wynne; Heather Heitkotter; Erica N. Woertz; Robert F. Cooper; Joseph Carroll
TAGS: diagnostic imaging, magnification, mosaicism, ophthalmoscopy, optics, retinal cone, photoreceptors, image quality
Trans. Vis. Sci. Tech.. 2022; 11(5):19. doi: https://doi.org/10.1167/tvst.11.5.19

Includes: Multimedia, Supplemental Content

Visual Neuroscience May 2022

The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease

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Kallene Summer Moreira Vidal; Diego Decleva; Mirella Telles Salgueiro Barboni; Balàzs Vince Nagy; Paulo Augusto Hidalgo de Menezes; Avinash Aher; Artur Martins Coutinho; Paula Squarzoni; Daniele de Paula Faria; Fabio Luis de Souza Duran; Carlos Alberto Buchpiguel; Jan Kremers; Geraldo Busatto Filho; Dora Fix Ventura
TAGS: alzheimer's disease, brain, color, color vision, electroretinography, heart failure, minimal cognitive impairment, nerve degeneration, positron-emission tomography
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):20. doi: https://doi.org/10.1167/iovs.63.5.20

Includes: Supplemental Content

Genetics May 2022

Autosomal Dominant Retinitis Pigmentosa–Associated TOPORS Protein Truncating Variants Are Exclusively Located in the Region of Amino Acid Residues 807 to 867

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Junwen Wang; Yingwei Wang; Yi Jiang; Xueqing Li; Xueshan Xiao; Shiqiang Li; Xiaoyun Jia; Wenmin Sun; Panfeng Wang; Qingjiong Zhang
TAGS: amino acids, proteins, retinitis pigmentosa, datasets, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):19. doi: https://doi.org/10.1167/iovs.63.5.19

Includes: Supplemental Content

Retina May 2022

Single-Cell Protein and Transcriptional Characterization of Epiretinal Membranes From Patients With Proliferative Vitreoretinopathy

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Yannik Laich; Julian Wolf; Rozina Ida Hajdu; Anja Schlecht; Felicitas Bucher; Laurenz Pauleikhoff; Martin Busch; Gottfried Martin; Henrik Faatz; Saskia Killmer; Bertram Bengsch; Andreas Stahl; Albrecht Lommatzsch; Günther Schlunck; Hansjürgen Agostini; Stefaniya Boneva; Clemens Lange
TAGS: epiretinal membrane, proteins, tissue membrane, transcription, genetic, vitreoretinopathy, proliferative, sequence analysis, rna, diagnostic imaging, body tissue
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):17. doi: https://doi.org/10.1167/iovs.63.5.17

Includes: Supplemental Content

Articles May 2022

Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases

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Carina M. Weigelt; Nina Zippel; Holger Fuchs; Anna-Kaisa Rimpelä; Tanja Schönberger; Birgit Stierstorfer; Remko A. Bakker; Norbert H. Redemann
TAGS: golimumab, inflammation, mice, retinal diseases, tumor necrosis factors
Trans. Vis. Sci. Tech.. 2022; 11(5):18. doi: https://doi.org/10.1167/tvst.11.5.18

Includes: Supplemental Content

Articles May 2022

Early Diagnosis and Quantitative Analysis of Stages in Retinopathy of Prematurity Based on Deep Convolutional Neural Networks

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Peng Li; Jia Liu
TAGS: convolutional neural networks, datasets, early diagnosis, retinopathy of prematurity, training, infant, premature, ophthalmologists
Trans. Vis. Sci. Tech.. 2022; 11(5):17. doi: https://doi.org/10.1167/tvst.11.5.17

Articles May 2022

Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry

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Thomas M. W. Buckley; Amandeep Singh Josan; Laura J. Taylor; Jasleen K. Jolly; Jasmina Cehajic-Kapetanovic; Robert E. MacLaren
TAGS: octopus, perimetry, retinitis pigmentosa, visual fields
Trans. Vis. Sci. Tech.. 2022; 11(5):15. doi: https://doi.org/10.1167/tvst.11.5.15

Articles May 2022

Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell–Inner Plexiform Layer Thickness

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Janelle Tong; Jack Phu; David Alonso-Caneiro; Sieu K. Khuu; Michael Kalloniatis
TAGS: cohort studies, ganglia, meridians, retinal cone, retinal ganglion cells
Trans. Vis. Sci. Tech.. 2022; 11(5):13. doi: https://doi.org/10.1167/tvst.11.5.13

Includes: Supplemental Content

Retina May 2022

Ablation of Ctrp9 , Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina

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Daiki Inooka; Yoshihiro Omori; Noriyuki Ouchi; Koji Ohashi; Yuto Kawakami; Yoshito Koyanagi; Chieko Koike; Hiroko Terasaki; Koji M. Nishiguchi; Shinji Ueno
TAGS: ligands, mice, retina, retinal cone, ablation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):14. doi: https://doi.org/10.1167/iovs.63.5.14

Includes: Supplemental Content

Retina May 2022

Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

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Wanjing Huang; Qiang Xu; Feng Liu; Jing Su; Dongchang Xiao; Lei Tang; Zhao-Zhe Hao; Ruifeng Liu; Kangjian Xiang; Yalan Bi; Zhichao Miao; Xialin Liu; Yizhi Liu; Sheng Liu
TAGS: abdominal compartment syndrome, acute coronary syndromes, american cancer society, american college of surgeons, mice, retina, immunohistochemistry, amacrine cells
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):13. doi: https://doi.org/10.1167/iovs.63.5.13

Includes: Supplemental Content

Articles May 2022

The NEI VFQ-25C: Calibrating Items in the National Eye Institute Visual Function Questionnaire-25 to Enable Comparison of Outcome Measures

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Judith E. Goldstein; Chris Bradley; Alden L. Gross; Marylou Jackson; Neil Bressler; Robert W. Massof
TAGS: eye, outcome measures, questionnaires, vision, datasets, rasch model
Trans. Vis. Sci. Tech.. 2022; 11(5):10. doi: https://doi.org/10.1167/tvst.11.5.10

Letters to the Editor May 2022

Re: Trivizki et al. Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

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Maximilian Pfau; Steffen Schmitz-Valckenberg; Frank G. Holz; Monika Fleckenstein
TAGS: atrophy, growth rate, macular neovascularization
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):10. doi: https://doi.org/10.1167/iovs.63.5.10

Letters to the Editor May 2022

Author Response: Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

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Omer Trivizki; Eric Michael Moult; Liang Wang; Prashanth Iyer; Yingying Shi; Giovanni Gregori; William Feuer; James G. Fujimoto; Philip J. Rosenfeld
TAGS: atrophy, growth rate, macular neovascularization
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):11. doi: https://doi.org/10.1167/iovs.63.5.11

Retina May 2022

Alpha-Smooth Muscle Actin Expression and Parafoveal Blood Flow Pathways Are Altered in Preclinical Diabetic Retinopathy

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Dong An; Jonathan Chung-Wah-Cheong; Dao-Yi Yu; Chandrakumar Balaratnasingam
TAGS: actins, blood capillaries, diabetic retinopathy, muscle, parafoveal region, vascular flow, donors, pericytes, perfusion, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):8. doi: https://doi.org/10.1167/iovs.63.5.8

Includes: Supplemental Content

Retina May 2022

Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders

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Yin-Hsi Chang; Eugene Yu-Chuan Kang; Pei-Kang Liu; Sarah R. Levi; Hung-Hsuan Wang; Yun-Ju Tseng; Go Hun Seo; Hane Lee; Lung-Kun Yeh; Kuan-Jen Chen; Wei-Chi Wu; Chi-Chun Lai; Laura Liu; Nan-Kai Wang
TAGS: mitochondria, optic atrophy, autosomal dominant, optic atrophy, hereditary, leber, optic nerve disorders, pathophysiology, photoreceptors, tissue degeneration, spectral domain-optical coherence tomography, mutation, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):5. doi: https://doi.org/10.1167/iovs.63.5.5

Includes: Supplemental Content

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Automated Assessment of Photoreceptor Visibility in Adaptive Optics Split-Detection Images Using Edge Detection

Different Phenotypes Represent Advancing Stages of ABCA4 -Associated Retinopathy: A Longitudinal Study of 212 Chinese Families From a Tertiary Center

Identification of a Complex Allele in IMPG2 as a Cause of Adult-Onset Vitelliform Macular Dystrophy

Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device

Sex and Age-Related Differences in Complement Factors Among Patients With Intermediate Age-Related Macular Degeneration

Comparison of Cone Mosaic Metrics From Images Acquired With the SPECTRALIS High Magnification Module and Adaptive Optics Scanning Light Ophthalmoscopy

The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease

Autosomal Dominant Retinitis Pigmentosa–Associated TOPORS Protein Truncating Variants Are Exclusively Located in the Region of Amino Acid Residues 807 to 867

Single-Cell Protein and Transcriptional Characterization of Epiretinal Membranes From Patients With Proliferative Vitreoretinopathy

Characterization and Validation of In Vitro and In Vivo Models to Investigate TNF-α-Induced Inflammation in Retinal Diseases

Early Diagnosis and Quantitative Analysis of Stages in Retinopathy of Prematurity Based on Deep Convolutional Neural Networks

Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry

Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell–Inner Plexiform Layer Thickness

Ablation of Ctrp9 , Ligand of AdipoR1, and Lower Number of Cone Photoreceptors in Mouse Retina

Identification of TPBG-Expressing Amacrine Cells in DAT-tdTomato Mouse

The NEI VFQ-25C: Calibrating Items in the National Eye Institute Visual Function Questionnaire-25 to Enable Comparison of Outcome Measures

Re: Trivizki et al. Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

Author Response: Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization

Alpha-Smooth Muscle Actin Expression and Parafoveal Blood Flow Pathways Are Altered in Preclinical Diabetic Retinopathy

Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders

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