Biochemistry and Molecular Biology

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Cornea December 2024

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

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Zhiwei Zha; Decheng Xiao; Zihao Liu; Fangli Peng; Xunjie Shang; Zhenzhen Sun; Yang Liu; Wei Chen
TAGS: cyclophosphamide, doxorubicin, prednisone, and vincristine, dry eye syndromes, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, stress, mice, endoplasmic reticulum, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):34. https://doi.org/10.1167/iovs.65.14.34

Includes: Supplemental Content

Retinal Cell Biology December 2024

Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis

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Joshua Glass; Rebekah Robinson; Neel Edupuganti; Jeremy Altman; Grace Greenway; Tae Jin Lee; Wenbo Zhi; Ashok Sharma; Shruti Sharma
TAGS: interleukin-6, proteins, neuroglia, mice, interleukin 6 receptor
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):33. https://doi.org/10.1167/iovs.65.14.33

Includes: Supplemental Content

Physiology and Pharmacology December 2024

Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome

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Ameya Belamkar; Qianyi Luo; Neha Mahajan; Surabhi Abhyankar; Bryce A. Jones; Rupinder Kaur Sodhi; Padmanabhan P. Pattabiraman; Moshe Levi; Ashay D. Bhatwadekar
TAGS: collagen, cornea, eye, eye diseases, fluorescent antibody technique, hereditary nephritis, lens (device), mice, mice, knockout, phenotype
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):29. https://doi.org/10.1167/iovs.65.14.29

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2024

Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease

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Bushra Rahman; David M. G. Anderson; Chunhe Chen; Jian Liu; Lukasz G. Migas; Raf Van de Plas; Kevin L. Schey; Masahiro Kono; Jie Fan; Yiannis Koutalos
TAGS: chromophore, mice, niemann-pick diseases, retina, sphingolipids, vitamin a, spectrometry, mass, matrix-assisted laser desorption-ionization, sphingomyelins, diagnostic imaging, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):24. https://doi.org/10.1167/iovs.65.14.24

Lens December 2024

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

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Yu Yang; Cong Fan; Yue Zhang; Tianyi Kang; Jian Jiang
TAGS: diabetes mellitus, lens (device), lens, crystalline, metabolites, mice, retina, streptozocin, metabolic disturbance, lipocalin-2 protein, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):19. https://doi.org/10.1167/iovs.65.14.19

Includes: Supplemental Content

Lens December 2024

Mefunidone Inhibits Inflammation, Oxidative Stress, and Epithelial-Mesenchymal Transition in Lens Epithelial Cells

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Cong Fan; Yu Yang; Mengling You; Zhuo Chen; Jian Jiang
TAGS: epithelial to mesenchymal transition, inflammation, lens epithelial cell, oxidative stress, surgical procedures, operative, western blotting, mitogen-activated protein kinases, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):17. https://doi.org/10.1167/iovs.65.14.17

Includes: Supplemental Content

Cornea December 2024

A Sex-Dependent Cannabinoid CB1 Receptor Role in Circadian Tearing of the Mouse

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Natalia Murataeva; Kyle Yust; Sam Mattox; Wenwen Du; Alex Straiker
TAGS: cannabinoids, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):10. https://doi.org/10.1167/iovs.65.14.10

Anatomy and Pathology/Oncology November 2024

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

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Lauren A. Dalvin; Cynthia M. Andrews-Pfannkoch; David R. Miley; Tara L. Hogenson; Samantha A. Erickson; Shivani Malpotra; Kjersten J. Anderson; Mohammed E. Omer; Luciana L. Almada; Cheng Zhang; Hu Li; Diva R. Salomao; Carol L. Shields; Sara E. Lally; Rachel M. Malsch; James A. Armitage; Heather L. Holmes; Michael F. Romero; Michael P. Fautsch; Svetomir N. Markovic; Martin E. Fernandez-Zapico
TAGS: intraocular melanoma, neoplasms, organoids, translational research, immunohistochemistry, bap1 gene, transplantation, heterologous, atac trial
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):60. https://doi.org/10.1167/iovs.65.13.60

Includes: Supplemental Content

Retinal Cell Biology November 2024

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

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Belinda J. Hernandez; Madison Strain; Maria Fernanda Suarez; W. Daniel Stamer; Allison Ashley-Koch; Yutao Liu; Mikael Klingeborn; Catherine Bowes Rickman
TAGS: micrornas, patient isolation, social isolation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):57. https://doi.org/10.1167/iovs.65.13.57

Includes: Supplemental Content

Physiology and Pharmacology November 2024

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

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Sabrina Wohlfart; Jonathan Herth; Manuel Ben Böhmann; Giulia Pander; Lorenz Herbster; Walter Mier; Gerd Uwe Auffarth; Philipp Uhl; Maximilian Hammer
TAGS: antibodies, anti-vascular endothelial growth factor therapy, bevacizumab, silicone oils, trastuzumab, vascular endothelial growth factor a, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):56. https://doi.org/10.1167/iovs.65.13.56

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2024

Metabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs

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Xueqi Lin; Changyue Zheng; Jing Cong; Qianhong Feng; Jiayue Yuan; Shichu Liu; Hao Li; Chenli Feng; Jinhui Dai
TAGS: glycine, lens (device), lens, crystalline, myopia, sclera, caviidae, metabolites, amino acids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):51. https://doi.org/10.1167/iovs.65.13.51

Artificial Intelligence November 2024

Associations of Metabolically Healthy Obesity and Retinal Age Gap

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Xiaomin Zeng; Ruiye Chen; Gabriella Bulloch; Qingsheng Peng; Ching-Yu Cheng; Mingguang He; Honghua Yu; Zhuoting Zhu
TAGS: obesity, obesity, metabolically benign, phenotype, body mass index procedure, body weight
Trans. Vis. Sci. Tech.. 2024; 13(11):26. https://doi.org/10.1167/tvst.13.11.26

Glaucoma November 2024

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

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Akiko Hanyuda; Yoshihiko Raita; Takahiro Ninomiya; Kazuki Hashimoto; Naoko Takada; Kota Sato; Jin Inoue; Seizo Koshiba; Gen Tamiya; Akira Narita; Masato Akiyama; Kazuko Omodaka; Satoru Tsuda; Yu Yokoyama; Noriko Himori; Yasuko Yamamoto; Takazumi Taniguchi; Kazuno Negishi; Toru Nakazawa
TAGS: glaucoma, metabolomics, open-angle glaucoma, multiomics, metabolites
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):44. https://doi.org/10.1167/iovs.65.13.44

Includes: Supplemental Content

Retinal Cell Biology November 2024

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

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Juliane Hammer; Paul Röppenack; Sarah Yousuf; Anja Machate; Marika Fischer; Stefan Hans; Michael Brand
TAGS: adult, zebrafish, phenotype, visual system, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):42. https://doi.org/10.1167/iovs.65.13.42

Includes: Supplemental Content

Retina November 2024

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

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Nicole A. Muench; Heather M. Schmitt; Cassandra L. Schlamp; An-Jey A. Su; Kia Washington; Robert W. Nickells
TAGS: cryopreservation, eye, mice
Trans. Vis. Sci. Tech.. 2024; 13(11):24. https://doi.org/10.1167/tvst.13.11.24

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

Retina November 2024

A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks

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Saman Ebrahimi; Phillip Bedggood; Yifu Ding; Andrew Metha; Prosenjit Bagchi
TAGS: blood capillaries, blood cells, computer simulation, fluid flow, hematocrit, hemodynamics, microcirculation, microvascular network, velocity, retail clinics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):37. https://doi.org/10.1167/iovs.65.13.37

Includes: Multimedia, Supplemental Content

Biochemistry and Molecular Biology November 2024

Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

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Seung Hyun Park; Soo Hyun Choi; Hyun Young Park; JaeSang Ko; Jin Sook Yoon
TAGS: body tissue, fibroblasts, oxidase, pathogenesis, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):33. https://doi.org/10.1167/iovs.65.13.33

Includes: Supplemental Content

Retina November 2024

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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Huan Liu; Feiyan Wang; Ziqing Hu; Jing Wei
TAGS: diabetic retinopathy, drug delivery systems, mendelian randomization analysis, plasma proteins, proteins
Trans. Vis. Sci. Tech.. 2024; 13(11):17. https://doi.org/10.1167/tvst.13.11.17

Includes: Supplemental Content

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Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

Proteomic Alterations in Retinal Müller Glial Cells Lacking Interleukin-6 Receptor: A Comprehensive Analysis

Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome

Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease

Untargeted Metabolomics Reveals the Role of Lipocalin-2 in the Pathological Changes of Lens and Retina in Diabetic Mice

Mefunidone Inhibits Inflammation, Oxidative Stress, and Epithelial-Mesenchymal Transition in Lens Epithelial Cells

A Sex-Dependent Cannabinoid CB1 Receptor Role in Circadian Tearing of the Mouse

Novel Uveal Melanoma Patient-Derived Organoid Models Recapitulate Human Disease to Support Translational Research

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

Exposure to Silicone Oil Endotamponades Induces VEGF Antibody Aggregation and Loss of Functionality

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

Metabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs

Associations of Metabolically Healthy Obesity and Retinal Age Gap

Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study

Blind But Alive – Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish

Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks

Role of Lysyl Oxidase-Like Protein 3 in the Pathogenesis of Graves’ Orbitopathy in Orbital Fibroblasts

Potential Drug Targets for Diabetic Retinopathy Identified Through Mendelian Randomization Analysis

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