Biochemistry and Molecular Biology

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Retina June 2023

Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina

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Thomas Stax Jakobsen; Jakob Appel Østergaard; Mads Kjolby; Elisa Lund Birch; Toke Bek; Anders Nykjaer; Thomas J. Corydon; Anne Louise Askou
TAGS: diabetes mellitus, mice, retina, nerve degeneration, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):8. doi: https://doi.org/10.1167/iovs.64.7.8

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2023

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

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Yanyan Xie; Yuan Pan; Qian Chen; Yuxi Chen; Guanyu Chen; Mei Wang; Peng Zeng; Zhuang Li; Zuoyi Li; Sha Wang; Huasheng Yang; Dan Liang
TAGS: fibrosis, forkhead box protein m1, graves' ophthalmopathy, fibroblasts, proteins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):9. doi: https://doi.org/10.1167/iovs.64.7.9

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2023

HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation

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Jing Zhang; Ning Jiang; Chunxiao Du; Hongzan Guo; Ranqi Meng; Xinyu Hou; Mugen Liu; Yanzhong Hu; Xiukun Cui
TAGS: autophagy, lens (device), lens, crystalline, mice, rapamycin, catabolism, organelles
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):5. doi: https://doi.org/10.1167/iovs.64.7.5

Includes: Supplemental Content

Biochemistry and Molecular Biology June 2023

The Mechanosensitive Piezo1 Channel Mediates Mechanochemical Transmission in Myopic Eyes

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Weiqi Zhong; Changjun Lan; Zhiming Gu; Qingqing Tan; Xiaoling Xiang; Hong Zhou; Xuan Liao
TAGS: eye, myopia, retina, caviidae, proteins, dimethyl sulfoxide
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):1. doi: https://doi.org/10.1167/iovs.64.7.1

Cornea May 2023

Z nf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome

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Jing Bao; Xiaoning Yu; Xiyuan Ping; Xingchao Shentu; Jian Zou
TAGS: cornea, ehlers-danlos syndrome 6b, mutation, zebrafish, regulation, larva
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):29. doi: https://doi.org/10.1167/iovs.64.5.29

Includes: Supplemental Content

Glaucoma May 2023

Influence of a Prostaglandin F2α Analogue on Corneal Hysteresis and Expression of Extracellular Matrix Metalloproteinases 3 and 9

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Constance Weber; Alexandra Buerger; Siegfried Priglinger; Karl Mercieca; Raffael Liegl
TAGS: cornea, corneal hysteresis, extracellular matrix, intraocular pressure, metalloproteases, prostaglandins, prostaglandins, synthetic, stromelysin 1, gelatinase b, donors
Trans. Vis. Sci. Tech.. 2023; 12(5):28. doi: https://doi.org/10.1167/tvst.12.5.28

Anatomy and Pathology/Oncology May 2023

Exogenous All- Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice

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Dillon M. Brown; Jianshi Yu; Praveen Kumar; Quinn M. Paulus; Michael A. Kowalski; Jay M. Patel; Maureen A. Kane; C. Ross Ethier; Machelle T. Pardue
TAGS: mice, myopia, sclera, tretinoin, biomechanics, eye
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):22. doi: https://doi.org/10.1167/iovs.64.5.22

Includes: Supplemental Content

Physiology and Pharmacology May 2023

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization

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Nan Shu; Zhi Zhang; Xiaotang Wang; Ruonan Li; Wanqian Li; Xianyang Liu; Qi Zhang; Zhengxuan Jiang; Liming Tao; Li Zhang; Shengping Hou
TAGS: autoimmunity, microglia, uveitis, toll-like receptor 4, western blotting, myd88 gene, proteins, inflammation
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):21. doi: https://doi.org/10.1167/iovs.64.5.21

Includes: Supplemental Content

Cornea May 2023

The TCF4 Trinucleotide Repeat Expansion of Fuchs’ Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye

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Jiaxin Hu; Xin Gong; Samantha T. Johnson; David R. Corey; V. Vinod Mootha
TAGS: body tissue, cornea, corneal endothelium, corneal stroma, endothelium, eye, hereditary corneal dystrophy, rna, trabecular meshwork, trinucleotide repeat expansion
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):16. doi: https://doi.org/10.1167/iovs.64.5.16

Includes: Supplemental Content

Retinal Cell Biology May 2023

Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies

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Gabriel E. Bertolesi; Maxwell F. J. Chilije; Victoria Li; Chase C. Thompson; Arturo López-Villalobos; Carrie L. Hehr; Karen Atkinson-Leadbeater; Vanina Zaremberg; Sarah McFarlane
TAGS: acyltransferase, eye, lipids, proteins, xenopus, embryo, yeasts, enzymes, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):17. doi: https://doi.org/10.1167/iovs.64.5.17

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology May 2023

Myofiber Type Shift in Extraocular Muscles in Amyotrophic Lateral Sclerosis

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Arvin Behzadi; Anton Erik Tjust; Jing-Xia Liu; Peter Munch Andersen; Thomas Brännström; Fatima Pedrosa Domellöf
TAGS: amyotrophic lateral sclerosis, antibodies, donors, muscle of orbit, synaptophysin, muscle, motor endplate
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):15. doi: https://doi.org/10.1167/iovs.64.5.15

Includes: Supplemental Content

Retinal Cell Biology May 2023

Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN

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Junji Hamuro; Tomoko Yamashita; Yohei Otsuki; Nao Hiramoto; Mayuka Adachi; Takafumi Miyatani; Hiroshi Tanaka; Morio Ueno; Shigeru Kinoshita; Chie Sotozono
TAGS: idiopathic pneumonia syndrome, mitochondria, pten gene, retinal pigment cell, extracellular vesicles, phenotype, homeostasis
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):9. doi: https://doi.org/10.1167/iovs.64.5.9

Includes: Supplemental Content

Immunology and Microbiology May 2023

Altered Functionality of Lipoprotein(a) Impacts on Angiogenesis in Diabetic Retinopathy

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Mahnaz Shariatzadeh; Nicole M. A. Nagtzaam; Leonie van Vark-van der Zee; Conny van Holten-Neelen; Adrie J. M. Verhoeven; Jonas Dehairs; Johannes V. Swinnen; Frank Leijten; Josianne C. ten Berge; Jose P. Martinez Ciriano; King T. Wong; Monique Mulder; Pieter J. M. Leenen; Willem A. Dik
TAGS: angiogenesis, diabetes mellitus, type 2, diabetic retinopathy, lipoproteins, low-density lipoproteins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(5):8. doi: https://doi.org/10.1167/iovs.64.5.8

Includes: Supplemental Content

Article May 2023

Cross-modal metacognition: Visual and tactile confidence share a common scale

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Lena Klever; Marie Christin Beyvers; Katja Fiehler; Pascal Mamassian; Jutta Billino
TAGS: judgment, metacognition, psychometrics, reaction time
Journal of Vision. 2023; 23(5):3. doi: https://doi.org/10.1167/jov.23.5.3

Immunology and Microbiology April 2023

Effects of Plasma-Derived Exosomal miRNA-19b-3p on Treg/T Helper 17 Cell Imbalance in Behçet's Uveitis

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Qingyan Jiang; Qingfeng Wang; Shiyao Tan; Jinyu Cai; Xingsheng Ye; Guannan Su; Peizeng Yang
TAGS: behcet syndrome, exosomes, imbalance, micrornas, plasma, regulatory t-lymphocytes, uveitis, th17 cells, cd46 antigen, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):28. doi: https://doi.org/10.1167/iovs.64.4.28

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2023

AURKB Enhances Chromosomal Remodeling of Telomeric Genes and Accelerates Tumorigenesis of Uveal Melanoma

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Huixue Wang; Hui Pan; Xiaolin Huang
TAGS: chromosomes, genes, intraocular melanoma, tumorigenesis, histone h3, sequence analysis, rna, mass or substance concentration per volume, telomere
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):23. doi: https://doi.org/10.1167/iovs.64.4.23

Includes: Supplemental Content

Lens April 2023

Nonmuscle Myosin IIA Regulates the Precise Alignment of Hexagonal Eye Lens Epithelial Cells During Fiber Cell Formation and Differentiation

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Sadia T. Islam; Catherine Cheng; Justin Parreno; Velia M. Fowler
TAGS: lens (device), lens, crystalline, epithelial cells, mice, myosins, nonmuscle myosin type iia
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):20. doi: https://doi.org/10.1167/iovs.64.4.20

Includes: Supplemental Content

Lens April 2023

BMP-4 and BMP-7 Inhibit EMT in a Model of Anterior Subcapsular Cataract in Part by Regulating the Notch Signaling Pathway

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Fanying Jiang; Yingyan Qin; Yuanfan Yang; Zhen Li; Baoyue Cui; Rong Ju; Mingxing Wu
TAGS: ambulatory surgery center, epithelial to mesenchymal transition, notch signaling pathway, subcapsular cataract, wounds and injuries, sequence analysis, rna, proteins, mice
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):12. doi: https://doi.org/10.1167/iovs.64.4.12

Includes: Supplemental Content

Immunology and Microbiology April 2023

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

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Zhiyuan Yu; Ghasem Yazdanpanah; Jehan Alam; Cintia S. de Paiva; Stephen Pflugfelder
TAGS: corneal epithelium, dry eye syndromes, nf-kappa b, stress, nlr family, pyrin domain-containing 3 protein, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):8. doi: https://doi.org/10.1167/iovs.64.4.8

Includes: Supplemental Content

Retina April 2023

The Relationship Between Retinal and Choroidal Thickness and Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus

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Hyun Seung Yang; Young Je Choi; Hee Yong Han; Hak Su Kim; So Hyun Park; Jeongmin Kim; Sangkyung Choi
TAGS: adiponectin, diabetes mellitus, type 2, hypertension, vascular endothelial growth factor a, cytokine
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):6. doi: https://doi.org/10.1167/iovs.64.4.6

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Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina

Selective BD2 Inhibitor Exerts Anti-Fibrotic Effects via BRD4/FoxM1/Plk1 Axis in Orbital Fibroblasts From Patients With Thyroid Eye Disease

HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation

The Mechanosensitive Piezo1 Channel Mediates Mechanochemical Transmission in Myopic Eyes

Z nf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome

Influence of a Prostaglandin F2α Analogue on Corneal Hysteresis and Expression of Extracellular Matrix Metalloproteinases 3 and 9

Exogenous All- Trans Retinoic Acid Induces Myopia and Alters Scleral Biomechanics in Mice

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization

The TCF4 Trinucleotide Repeat Expansion of Fuchs’ Endothelial Corneal Dystrophy: Implications for the Anterior Segment of the Eye

Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies

Myofiber Type Shift in Extraocular Muscles in Amyotrophic Lateral Sclerosis

Spatiotemporal Coordination of RPE Cell Quality by Extracellular Vesicle miR-494-3p Via Competitive Interplays With SIRT3 or PTEN

Altered Functionality of Lipoprotein(a) Impacts on Angiogenesis in Diabetic Retinopathy

Cross-modal metacognition: Visual and tactile confidence share a common scale

Effects of Plasma-Derived Exosomal miRNA-19b-3p on Treg/T Helper 17 Cell Imbalance in Behçet's Uveitis

AURKB Enhances Chromosomal Remodeling of Telomeric Genes and Accelerates Tumorigenesis of Uveal Melanoma

Nonmuscle Myosin IIA Regulates the Precise Alignment of Hexagonal Eye Lens Epithelial Cells During Fiber Cell Formation and Differentiation

BMP-4 and BMP-7 Inhibit EMT in a Model of Anterior Subcapsular Cataract in Part by Regulating the Notch Signaling Pathway

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

The Relationship Between Retinal and Choroidal Thickness and Adiponectin Concentrations in Patients With Type 2 Diabetes Mellitus

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