Biochemistry and Molecular Biology

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Retina September 2024

Model Predictive Temperature Control for Retinal Laser Treatments

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Viktoria Kleyman; Sophie Eggert; Christian Schmidt; Manuel Schaller; Karl Worthmann; Ralf Brinkmann; Matthias A. Müller
TAGS: body temperature regulation, laser therapy, lasers, process of absorption, temperature, body temperature, eye
Trans. Vis. Sci. Tech.. 2024; 13(9):28. https://doi.org/10.1167/tvst.13.9.28

Cornea September 2024

RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus

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Yunhai Dai; Shilan Mao; Xinyi Zang; Hongqi Ge; Jing Feng; Yalin Wang; Xia Qi; Lingling Yang; Qingjun Zhou; Xiaolei Wang
TAGS: cornea, diabetes mellitus, type 2, human herpesvirus 1, infections, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):36. https://doi.org/10.1167/iovs.65.11.36

Includes: Supplemental Content

Retinal Cell Biology September 2024

Blue Light-Induced Accelerated Formation of Melanolipofuscin-Like Organelles in Japanese Quail RPE Cells: An Electron Microscopic Study

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Natalia B. Serejnikova; Natalia N. Trofimova; Marina A. Yakovleva; Alexander E. Dontsov; Pavel P. Zak; Mikhail A. Ostrovsky
TAGS: granules, japanese, lipofuscin, organelles, quail, retinal pigment cell, langer-giedion syndrome, melanins, melanosomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):31. https://doi.org/10.1167/iovs.65.11.31

Lens September 2024

Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithelium

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Chun-Hong Xia; William Lin; Rachel Li; Xinfang Xing; Guangdu Jack Shang; Haiwei Zhang; Xiaohua Gong
TAGS: aquaporin 1, gap junction protein, lens (device), lens epithelial cell, lens epithelium, lens, crystalline, rna, small cytoplasmic, mice, western blotting, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):27. https://doi.org/10.1167/iovs.65.11.27

Includes: Supplemental Content

Lens September 2024

Prospective Cytokine Profiling in Aqueous Humor Reveals a Proinflammatory Microenvironment in Highly Dense Nuclear Cataracts

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Catharina Latz; Annika Licht; Alireza Mirshahi; Eicke Latz; Kai Zimmer
TAGS: aqueous humor, cataract, nuclear, cytokine, hypertension, cataract, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):25. https://doi.org/10.1167/iovs.65.11.25

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2024

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization

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Ying Yang; Shenglai Zhang; Shu Su; Xiaowei Yang; Jia Chen; Aimin Sang
TAGS: choroidal neovascularization, circadian rhythms, mice, circadian rhythm disorders, proteins, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):21. https://doi.org/10.1167/iovs.65.11.21

Includes: Supplemental Content

Retina September 2024

A Mathematical Model of Interstitial Fluid Flow and Retinal Tissue Deformation in Macular Edema

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Alessia Ruffini; Mariia Dvoriashyna; Andrea Govetto; Mario R. Romano; Rodolfo Repetto
TAGS: body tissue, fluid flow, macular edema, retina, minimally conscious state, mathematical model, mast-cell sarcoma, interstitial fluid, cardiac support procedures, millennium cohort study
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):19. https://doi.org/10.1167/iovs.65.11.19

Biochemistry and Molecular Biology September 2024

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

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Saira Rizwan; Beverly Toothman; Bo Li; Abbi L. Engel; Rayne R. Lim; Sheldon Niernberger; Jinyu Lu; Cloe Ratliff; Yinxiao Xiang; Mark Eminhizer; Jennifer R. Chao; Jianhai Du
TAGS: glutamine, nutrients, phenotype determination, retinal pigment cell, sugars, induced pluripotent stem cells, amino acids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):5. https://doi.org/10.1167/iovs.65.11.5

Includes: Supplemental Content

Retina September 2024

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab

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Takahito Todoroki; Jun Takeuchi; Hikaru Ota; Yuyako Nakano; Ai Fujita Sajiki; Koichi Nakamura; Hiroki Kaneko; Koji M. Nishiguchi
TAGS: aflibercept, age-related macular degeneration, aqueous humor, cytokine, faricimab, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):15. https://doi.org/10.1167/iovs.65.11.15

Cornea & External Disease September 2024

Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study

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Yuan Chang; Tianze Huang; Shan Yang; Ying Li; Di Chen
TAGS: atopic dermatitis, keratoconus, mendelian randomization analysis, genome-wide association study, datasets
Trans. Vis. Sci. Tech.. 2024; 13(9):13. https://doi.org/10.1167/tvst.13.9.13

Includes: Supplemental Content

Cornea September 2024

RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing

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Rajnish Kumar; Ratnakar Tripathi; Nishant R. Sinha; Rajiv R. Mohan
TAGS: cornea, genes, rna-seq, wound healing, proteins, rna, polymerase chain reaction, myofibroblasts
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):13. https://doi.org/10.1167/iovs.65.11.13

Includes: Supplemental Content

Retina September 2024

Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia

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Ying Ling; Yao Wang; Jingjing Ye; Changlin Luan; Ailing Bi; Yu Gu; Xuefeng Shi
TAGS: dopamine, eye, myopia, retina, sutures, amacrine cells, retinal ganglion cells, vesicular monoamine transporter 2, melanopsin, pituitary adenylate cyclase activating polypeptide
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):8. https://doi.org/10.1167/iovs.65.11.8

Includes: Supplemental Content

Artificial Intelligence September 2024

Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method

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Najung Kim; Minsub Lee; Hyewon Chung; Hyung Chan Kim; Hyungwoo Lee
TAGS: age-related macular degeneration, anti-vascular endothelial growth factor therapy, cohort studies, diagnostic imaging, drug loading dose, injections, machine learning, visual acuity, treatment protocols, eye
Trans. Vis. Sci. Tech.. 2024; 13(9):3. https://doi.org/10.1167/tvst.13.9.3

Includes: Supplemental Content

Retinal Cell Biology September 2024

Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway

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Furong Gao; Mengwen Li; Lilin Zhu; Jiao Li; Jie Xu; Song Jia; Qingjian Ou; Caixia Jin; Haibin Tian; Juan Wang; Jingying Xu; Wei Xu; Guo-Tong Xu; Lixia Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, epithelial to mesenchymal transition, phosphoinositide 3-kinase, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):1. https://doi.org/10.1167/iovs.65.11.1

Includes: Supplemental Content

Cornea August 2024

The Necroptosis Pathway Is Upregulated in the Cornea in Mice With Ocular Graft-Versus-Host Disease

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Kazuki Asai; Hyung Keun Lee; Shinri Sato; Eisuke Shimizu; Jaehun Jung; Takahiro Okazaki; Mamoru Ogawa; Shigeto Shimmura; Kazuo Tsubota; Yoko Ogawa; Kazuno Negishi; Masatoshi Hirayama
TAGS: cornea, graft-versus-host disease, mice, necroptosis, proteins, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):38. https://doi.org/10.1167/iovs.65.10.38

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2024

Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8 + T Cells and in Uveal Melanoma

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Chen Hou; Qi Wan; Lirong Xiao; Qing Xiao; Meixia Zhang; Naihong Yan
TAGS: heme oxygenase (decyclizing), intraocular melanoma, neoplasms, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):37. https://doi.org/10.1167/iovs.65.10.37

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2024

Agonism of β3-Adrenoceptors Inhibits Pathological Retinal Angiogenesis in the Model of Oxygen-Induced Retinopathy

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Alberto Melecchi; Alessio Canovai; Rosario Amato; Massimo Dal Monte; Luca Filippi; Paola Bagnoli; Maurizio Cammalleri
TAGS: adrenergic receptor, angiogenesis, astrocytes, did not receive therapy or drug, hypoxia, mice, oxygen, proteins, retina, retinal diseases
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):34. https://doi.org/10.1167/iovs.65.10.34

Includes: Supplemental Content

Glaucoma August 2024

Comparison of SNCG and NEFH Promoter–Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma

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Nuala O'Neill; Miranda Meng; Brahim Chaqour; Kimberly Dine; Neha Sarabu; Jennifer C. Pham; Kenneth S. Shindler; Ahmara G. Ross
TAGS: glaucoma, mice, spatial vectors, enhancer of transcription, genes, cytomegalovirus
Trans. Vis. Sci. Tech.. 2024; 13(8):37. https://doi.org/10.1167/tvst.13.8.37

Retina August 2024

Retinal Penetrating Adeno-Associated Virus

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Binit Kumar; Manish Mishra; Siobhan Cashman; Rajendra Kumar-Singh
TAGS: adeno-associated virus, capsid, green fluorescent proteins, injections, intravitreal injections, mice, oxidative stress, peptides, photoreceptors, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):30. https://doi.org/10.1167/iovs.65.10.30

Includes: Multimedia, Supplemental Content

Retinal Cell Biology August 2024

Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons

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Jie Meng; Xiu Mei Yang; Oliver Scheer; Johannes Lange; Heidi Müller; Susanne Bürger; Sven Rothemund; Ruaa Younis; Jan D. Unterlauft; Wolfram Eichler
TAGS: vegfr-1, vascular endothelial growth factor receptors, retinal neurons, pigment, placenta growth factor, vascular endothelial growth factor a, epithelium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):27. https://doi.org/10.1167/iovs.65.10.27

Includes: Supplemental Content

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Model Predictive Temperature Control for Retinal Laser Treatments

RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus

Blue Light-Induced Accelerated Formation of Melanolipofuscin-Like Organelles in Japanese Quail RPE Cells: An Electron Microscopic Study

Altered Cell Clusters and Upregulated Aqp1 in Connexin 50 Knockout Lens Epithelium

Prospective Cytokine Profiling in Aqueous Humor Reveals a Proinflammatory Microenvironment in Highly Dense Nuclear Cataracts

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization

A Mathematical Model of Interstitial Fluid Flow and Retinal Tissue Deformation in Macular Edema

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

Aqueous Humor Cytokine Analysis in Age-Related Macular Degeneration After Switching From Aflibercept to Faricimab

Causal Association Between Atopic Dermatitis and Keratoconus: A Mendelian Randomization Study

RNA-Seq Analysis Unraveling Novel Genes and Pathways Influencing Corneal Wound Healing

Changes in Intrinsically Photosensitive Retinal Ganglion Cells, Dopaminergic Amacrine Cells, and Their Connectivity in the Retinas of Lid Suture Myopia

Prediction of Post-Treatment Visual Acuity in Age-Related Macular Degeneration Patients With an Interpretable Machine Learning Method

Knockdown of HSPA13 Inhibits TGFβ1-Induced Epithelial-Mesenchymal Transition of RPE by Suppressing the PI3K/Akt Signaling Pathway

The Necroptosis Pathway Is Upregulated in the Cornea in Mice With Ocular Graft-Versus-Host Disease

Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8 + T Cells and in Uveal Melanoma

Agonism of β3-Adrenoceptors Inhibits Pathological Retinal Angiogenesis in the Model of Oxygen-Induced Retinopathy

Comparison of SNCG and NEFH Promoter–Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma

Retinal Penetrating Adeno-Associated Virus

Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons

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