External Eye Disease

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Cornea June 2024

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

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Na Lin; Xin Chen; Haixia Liu; Ning Gao; Zhao Liu; Jin Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: dry eye syndromes, interleukin-13, mice, mucins, ocular surfaces, conjunctiva, balance, device, equilibrium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):39. https://doi.org/10.1167/iovs.65.6.39

Artificial Intelligence June 2024

Enhancing Meibography Image Analysis Through Artificial Intelligence–Driven Quantification and Standardization for Dry Eye Research

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Chun-Hsiao Yeh; Andrew D. Graham; Stella X. Yu; Meng C. Lin
TAGS: artificial intelligence, datasets, dreams, dry eye syndromes, eyelid, masks, tarsal plate, learning
Trans. Vis. Sci. Tech.. 2024; 13(6):16. https://doi.org/10.1167/tvst.13.6.16

Immunology and Microbiology June 2024

Lid Margin Microbiome in Stevens-Johnson Syndrome Patients With Lid Margin Keratinization and Severe Dry Eye Disease

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Swati Singh; Moumi Maity; Swapna Shanbhag; Kotakonda Arunasri; Sayan Basu
TAGS: dry eye syndromes, eyelid margin, keratinization, microbiome, stevens-johnson syndrome, eyelid
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):28. https://doi.org/10.1167/iovs.65.6.28

Includes: Supplemental Content

Cornea June 2024

Fosfenopril Attenuates Inflammatory Response in Diabetic Dry Eye Models by Inhibiting the TLR4/NF-κB/NLRP3 Signaling Pathway

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Kaiwen Jiang; Fenglan Zhang; Ying Chen; Xiaojing Li; Xinmei Zhao; Pengfei Jiang; Yuanbin Li
TAGS: diabetes mellitus, dry eye syndromes, glucose, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, toll-like receptor 4, mice, cornea, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):2. https://doi.org/10.1167/iovs.65.6.2

Cornea & External Disease May 2024

Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model

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Chih-Chien Hsu; Hao-Kai Chuang; Yu-Jer Hsiao; Pin-Hsuan Chiang; Szu-Wen Chen; Wei-Ting Luo; Yi-Ping Yang; Ping-Hsing Tsai; Shih-Jen Chen; Ai-Ru Hsieh; Shih-Hwa Chiou
TAGS: dry eye syndromes, genome, genome-wide association study, polygenic risk score
Trans. Vis. Sci. Tech.. 2024; 13(5):13. https://doi.org/10.1167/tvst.13.5.13

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2024

Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease

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Yang Tang; Shengqian Dou; Chao Wei; Ziwen Sun; Di Sun; Qingjun Zhou; Lixin Xie
TAGS: acinar cells, cell nucleus, dry eye syndromes, genes, heterogeneity, immunologic cells, lacrimal gland, langer-giedion syndrome, mice, scopolamine
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):46. https://doi.org/10.1167/iovs.65.4.46

Includes: Supplemental Content

Cornea April 2024

Mitochondrial DNA-Activated cGAS-STING Signaling in Environmental Dry Eye

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Xiying Tan; Qianqian Chen; Zhonghua Chen; Zhenzhen Sun; Wei Chen; Ruifen Wei
TAGS: dna, dna, mitochondrial, dry eye syndromes, mitochondria, signal transduction, mice, cytoplasm
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):33. https://doi.org/10.1167/iovs.65.4.33

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2024

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

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Wenyue Zhang; Huan Huang; Xueru Liu; Leilei Zhang; Lunhao Li; Yi Ding; Yichuan Xiao; Mohammad Javed Ali; Hao Sun; Caiwen Xiao
TAGS: epithelial cells, genes, lacrimal sac, nasolacrimal duct obstruction, pathogenesis, rna, small cytoplasmic, neutrophils, b-lymphocytes, inflammation, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):38. https://doi.org/10.1167/iovs.65.3.38

Includes: Supplemental Content

Letters to the Editor March 2024

Concerns About a Dog Model of Dry Eye Disease

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Ron Ofri; Nicholas J. Millichamp; Charlotte Keller; Gillian J. McLellan; András M. Komáromy; David Morton; Màrian Matas; Tammy M. Michau; Sarah Coall; Jane Sansom; Brian C Leonard
TAGS: dog, domestic, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(3):28. https://doi.org/10.1167/tvst.13.3.28

Letters to the Editor March 2024

Author Response: Concerns About a Dog Model of Dry Eye Disease

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Zhi-Zheng Li; Yan-Ping Zou; Hui Zhu; Wei-Zhen Zeng; Yi Ding; Jia-Zeng Su; Guang-Yan Yu
TAGS: dog, domestic, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(3):26. https://doi.org/10.1167/tvst.13.3.26

Clinical Trials March 2024

OCTA Signal Quality Augmentation Using the Isometric Handgrip Test to Maximize Vascular Flow (SQUEEZE): A Randomized Crossover Trial

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Matt Trinh; Judy Nam; Meenakshi Kumar; Lisa Nivison-Smith
TAGS: vascular flow, eye, grip strength
Trans. Vis. Sci. Tech.. 2024; 13(3):22. https://doi.org/10.1167/tvst.13.3.22

Includes: Supplemental Content

Cornea & External Disease February 2024

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

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Filippo Bonelli; Fabiola Campestre; Romina Mayra Lasagni Vitar; Ibrahim Halil Demirsoy; Philippe Fonteyne; Giulio Ferrari
TAGS: aprepitant, cornea, pain, signs and symptoms, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(2):9. https://doi.org/10.1167/tvst.13.2.9

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2024

Regional Conjunctival Differences in Glycocalyx Mucin Expression in Dry Eye and Normal Subjects

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Moonjung Choi; Anna Ablamowicz Tichenor
TAGS: conjunctiva, dry eye syndromes, glycocalyx, mucins, proteins, nose, eyelid
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):20. https://doi.org/10.1167/iovs.65.2.20

Includes: Supplemental Content

Review February 2024

Role of Serine Protease Inhibitors A1 and A3 in Ocular Pathologies

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Richard Kontoh-Twumasi; Stepan Budkin; Neel Edupuganti; Ayushi Vashishtha; Shruti Sharma
TAGS: eye diseases, serine proteinase inhibitors, signal transduction, serpins, uveitis, proteins, cataract, glaucoma, pterygium, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):16. https://doi.org/10.1167/iovs.65.2.16

Cornea February 2024

Urban Particulate Matter Triggers Meibomian Gland Dysfunction

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Mengqian Tu; Ren Liu; Jianwen Xue; Bing Xiao; Jing Li; Lingyi Liang
TAGS: meibomian gland dysfunction, mice, particulate matter, proteins, precipitating factors, western blotting, nlr family, pyrin domain-containing 3 protein, immunohistochemistry, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):8. https://doi.org/10.1167/iovs.65.2.8

Public Health January 2024

Trends in Health Service Use for Dry Eye Disease From 2017 to 2021: A Real-World Analysis of 369,755 Outpatient Visits

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Qinyi Gu; Qinxiang Zheng; Xiaoyu Zhang; Lei Lin; Saiqing Li; Fangwei Chen; Xian Zhang; Lijing L. Yan; Wei Chen
TAGS: dry eye syndromes, health services, outpatients, trend
Trans. Vis. Sci. Tech.. 2024; 13(1):17. https://doi.org/10.1167/tvst.13.1.17

Includes: Supplemental Content

Cornea January 2024

KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye

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Kai Liao; Hao Zeng; Xue Yang; Dalian He; Bowen Wang; Jin Yuan
TAGS: autophagy, corneal epithelial cells, dry eye syndromes, potassium, pyroptosis, tnf-related apoptosis-inducing ligand, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):34. https://doi.org/10.1167/iovs.65.1.34

Includes: Supplemental Content

Cornea January 2024

Sjögren's Versus Non-Sjögren's Ocular Features: Similar Symptoms, But Significantly Worse Signs

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Fanxiu Xiong; Douglas Pula; Esen K. Akpek; Vatinee Y. Bunya; Caroline H. Shiboski; Thomas L. Lietman; John A. Gonzales
TAGS: ocular signs and symptoms, signs and symptoms, sjogren's syndrome, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):23. https://doi.org/10.1167/iovs.65.1.23

Includes: Supplemental Content

Cornea January 2024

Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye

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Yifan Zhou; Baikai Ma; Qiyao Liu; Hongyu Duan; Yangbo Huo; Lu Zhao; Jiawei Chen; Wenling Han; Hong Qi
TAGS: cornea, dry eye syndromes, epithelium, inflammation, inflammatory response, integral membrane proteins, mice, stress, western blotting, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):4. https://doi.org/10.1167/iovs.65.1.4

Includes: Supplemental Content

Cornea & External Disease December 2023

Noninvasive Imaging of Conjunctival Goblet Cells as a Method for Diagnosing Dry Eye Disease in an Experimental Mouse Model

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Jeongho Kim; Jungbin Lee; Seonghan Kim; Sook Hyun Yoon; Yeong Chae Jo; Ki Hean Kim; Hong Kyun Kim
TAGS: conjunctiva, diagnostic imaging, dry eye syndromes, goblet cells, mice, cyclosporine
Trans. Vis. Sci. Tech.. 2023; 12(12):22. https://doi.org/10.1167/tvst.12.12.22

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Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

Enhancing Meibography Image Analysis Through Artificial Intelligence–Driven Quantification and Standardization for Dry Eye Research

Lid Margin Microbiome in Stevens-Johnson Syndrome Patients With Lid Margin Keratinization and Severe Dry Eye Disease

Fosfenopril Attenuates Inflammatory Response in Diabetic Dry Eye Models by Inhibiting the TLR4/NF-κB/NLRP3 Signaling Pathway

Predicting Risks of Dry Eye Disease Development Using a Genome-Wide Polygenic Risk Score Model

Single-Nuclei Characterization of Lacrimal Gland in Scopolamine-Induced Dry Eye Disease

Mitochondrial DNA-Activated cGAS-STING Signaling in Environmental Dry Eye

scRNA-Seq: First Atlas and Cellular Landscape of Lacrimal Sac: Implications in Primary Acquired Nasolacrimal Duct Obstruction Pathogenesis

Concerns About a Dog Model of Dry Eye Disease

Author Response: Concerns About a Dog Model of Dry Eye Disease

OCTA Signal Quality Augmentation Using the Isometric Handgrip Test to Maximize Vascular Flow (SQUEEZE): A Randomized Crossover Trial

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

Regional Conjunctival Differences in Glycocalyx Mucin Expression in Dry Eye and Normal Subjects

Role of Serine Protease Inhibitors A1 and A3 in Ocular Pathologies

Urban Particulate Matter Triggers Meibomian Gland Dysfunction

Trends in Health Service Use for Dry Eye Disease From 2017 to 2021: A Real-World Analysis of 369,755 Outpatient Visits

KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry Eye

Sjögren's Versus Non-Sjögren's Ocular Features: Similar Symptoms, But Significantly Worse Signs

Transmembrane Protein CMTM6 Alleviates Ocular Inflammatory Response and Improves Corneal Epithelial Barrier Function in Experimental Dry Eye

Noninvasive Imaging of Conjunctival Goblet Cells as a Method for Diagnosing Dry Eye Disease in an Experimental Mouse Model

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