Eye Anatomy and Disorders

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Retina January 2025

A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

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Hongling Liu; Xue Zhang; Qing Wang; Bowen Li; Baishijiao Bian; Yong Liu
TAGS: aging, gene expression, genes, retina, rna, small cytoplasmic, sequence analysis, rna, sex characteristics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):28. https://doi.org/10.1167/iovs.66.1.28

Includes: Supplemental Content

Lens January 2025

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract

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Wenjing Geng; Pengfei Li; Guowei Zhang; Renhao Zhong; Linhui Xu; Lihua Kang; Xi Liu; Miaomiao Wu; Min Ji; Huaijin Guan
TAGS: cataract, cortical cataract, paraptosis, lens, crystalline, lens epithelial cell, lens (device)
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):29. https://doi.org/10.1167/iovs.66.1.29

Includes: Supplemental Content

Physiology and Pharmacology January 2025

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

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Nina Riddell; Melanie J. Murphy; Sania Zahra; Isabella Robertson-Dixon; Sheila G. Crewther
TAGS: eye, lens (device), lens, crystalline, myopia, white light, blue light, refraction, photopsia, electroretinography, weight gain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):30. https://doi.org/10.1167/iovs.66.1.30

Includes: Supplemental Content

Retina January 2025

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity

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Francesco Gelormini; Federico Ricardi; Guglielmo Parisi; Veronica Vallino; Beatrice Ghezzo; Claudia Cucciarelli; Paola Marolo; Maria Vittoria Cicinelli; Andrea Govetto; Mario R. Romano; Enrico Borrelli; Michele Reibaldi
TAGS: biological markers, epiretinal membrane, visual acuity, reading (activity), near visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):31. https://doi.org/10.1167/iovs.66.1.31

Low Vision Rehabilitation January 2025

Performance on Activities of Daily Living and User Experience When Using Artificial Intelligence by Individuals With Vision Impairment

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William Seiple; Hilde P. A. van der Aa; Fernanda Garcia-Piña; Izekiel Greco; Calvin Roberts; Ruth van Nispen
TAGS: activities of daily living, artificial intelligence, blindness, visual impairment, perception
Trans. Vis. Sci. Tech.. 2025; 14(1):3. https://doi.org/10.1167/tvst.14.1.3

Retina January 2025

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

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Ines D. Nagel; Anna Heinke; Akshay P. Agnihotri; Shaden Yassin; Lingyun Cheng; Andrew S. Camp; Nathan L. Scott; Fritz Gerald P. Kalaw; Shyamanga Borooah; Dirk-Uwe G. Bartsch; Arthur J. Mueller; Nehal Mehta; William R. Freeman
TAGS: color, diagnostic imaging, lasers, minimal cognitive impairment, ophthalmoscopes, retinal imaging
Trans. Vis. Sci. Tech.. 2025; 14(1):11. https://doi.org/10.1167/tvst.14.1.11

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

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Brandon D. Anderson; Brent A. Bell; Ying Song; Timothy T. Lee; Tan Wang; Joshua L. Dunaief
TAGS: age-related macular degeneration, nonexudative, atrophy, injections, iodates, sodium, mice, diagnostic imaging, retina
Trans. Vis. Sci. Tech.. 2025; 14(1):9. https://doi.org/10.1167/tvst.14.1.9

Includes: Supplemental Content

Public Health January 2025

Social Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population

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Po-Jen Lin; Alison G. Abraham; Pradeep Ramulu; Aleks Mihailovic; Anna Kucharska-Newton; Xinxing Guo
TAGS: community, eye, older adult, social determinants of health, visual impairment, physicians, aric trial, health, income
Trans. Vis. Sci. Tech.. 2025; 14(1):8. https://doi.org/10.1167/tvst.14.1.8

Includes: Supplemental Content

Retina January 2025

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

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Federico Corti; Filippo Locri; Flavia Plastino; Paola Perrotta; Krisztina Zsebo; Emma Ristori; Xiangyun Yin; Eric Song; Helder André; Michael Simons
TAGS: antibodies, choroidal neovascularization, edema, inflammation, lasers, mice, syndecan, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, intravitreal injections
Trans. Vis. Sci. Tech.. 2025; 14(1):10. https://doi.org/10.1167/tvst.14.1.10

Includes: Supplemental Content

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Lens January 2025

Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens

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Nawal K. Khadka; Dieter Haemmerle; Paul H. Davis; Laxman Mainali
TAGS: lens (device), lens, crystalline, nuclear envelope, tissue membrane, cattle, lipids
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):27. https://doi.org/10.1167/iovs.66.1.27

Retina January 2025

Retinal Sensitivity in KCNV2 -Associated Retinopathy

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Thales A. C. de Guimaraes; Isabela M. C. de Guimaraes; Manickam Nick Muthiah; Angelos Kalitzeos; Michel Michaelides
TAGS: retinal diseases, visual acuity, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):26. https://doi.org/10.1167/iovs.66.1.26

Letters to the Editor January 2025

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

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Blondy Kayembe Mulumba; Karen Leffondré; Pierre Joly; Marie-Noëlle Delyfer; Cécile Delcourt
TAGS: age-related macular degeneration, genetics, statins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):25. https://doi.org/10.1167/iovs.66.1.25

Cornea January 2025

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

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Nishant R. Sinha; Alexandria C. Hofmann; Laila A. Suleiman; Maxwell T. Jeffrey; William C. Jeffrey; Rajnish Kumar; Ratnakar Tripathi; Rajiv R. Mohan
TAGS: corneal injuries, ferroptosis, mitogen-activated protein kinase p38, mustard gas, signal transduction, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):23. https://doi.org/10.1167/iovs.66.1.23

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2025

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

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Qiongjie Cao; Wenji Xu; Xiaoyan Chen; Guangying Luo; Peter S. Reinach; Dongsheng Yan
TAGS: arginine, cornea, epigenetics, epithelium, methylation, wound healing, regulation, mice, western blotting, histones
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):22. https://doi.org/10.1167/iovs.66.1.22

Includes: Supplemental Content

Cornea January 2025

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

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Chun-Hsiang Chang; I-Chen Peng; Yi-Hsun Huang
TAGS: alkalies, burns, cornea, macrophage activation, thrombomodulin, wound healing
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):21. https://doi.org/10.1167/iovs.66.1.21

Cornea January 2025

miRNA Expression Profile in Primary Limbal Epithelial Cells of Aniridia Patients

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Mahsa Nastaranpour; Shweta Suiwal; Tanja Stachon; Fabian N. Fries; Maryam Amini; Berthold Seitz; Eckart Meese; Nicole Ludwig; Nóra Szentmáry
TAGS: aniridia, epithelial cells, micrornas, candidate disease gene
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):20. https://doi.org/10.1167/iovs.66.1.20

Includes: Supplemental Content

Article January 2025

Eye posture and screen alignment with simulated see-through head-mounted displays

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Agostino Gibaldi; Yinghua Liu; Christos Kaspiris-Rousellis; Madhumitha S. Mahadevan; Jenny C. A. Read; Björn N. S. Vlaskamp; Gerrit W. Maus
TAGS: eye, posture
Journal of Vision. 2025; 25(1):9. https://doi.org/10.1167/jov.25.1.9

Includes: Supplemental Content

Article January 2025

Target interception in virtual reality is better for natural versus unnatural trajectory shapes and orientations

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Sofia Varon; Karsten Babin; Miriam Spering; Jody C. Culham
TAGS: shape, virtual reality, visual fields, reaction time, motion, movement time
Journal of Vision. 2025; 25(1):11. https://doi.org/10.1167/jov.25.1.11

Includes: Supplemental Content

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A Comprehensive Analysis of Sex-Biased Gene Expression in the Aging Human Retina Through a Combination of Single-Cell and Bulk RNA Sequencing

Targeted Activation of OGG1 Inhibits Paraptosis in Lens Epithelial Cells of Early Age-Related Cortical Cataract

Broadband Long Wavelength Light Promotes Myopic Eye Growth and Alters Retinal Responses to Light Offset in Chick

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity

Performance on Activities of Daily Living and User Experience When Using Artificial Intelligence by Individuals With Vision Impairment

Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy

Social Determinants of Uncorrected Distance and Near Visual Impairment in an Older Adult Population

Anti-Syndecan 2 Antibody Treatment Reduces Edema Formation and Inflammation of Murine Laser-Induced CNV

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens

Retinal Sensitivity in KCNV2 -Associated Retinopathy

Unveiling Statins and Genetics in Age-Related Macular Degeneration Progression: What Is the Appropriate Modeling Strategy?

Mustard Gas Induced Corneal Injury Involves Ferroptosis and p38 MAPK Signaling

PRMT1-Mediated Arginine Methylation Promotes Corneal Epithelial Wound Healing via Epigenetic Regulation of ANXA3

Recombinant Thrombomodulin Domain 1 Modulates Macrophage Polarization and Enhances Healing in Corneal Alkali Burns

miRNA Expression Profile in Primary Limbal Epithelial Cells of Aniridia Patients

Eye posture and screen alignment with simulated see-through head-mounted displays

Target interception in virtual reality is better for natural versus unnatural trajectory shapes and orientations

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Eye Anatomy and Disorders

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