Eye Anatomy and Disorders

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Cornea May 2025

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

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Runze Zhang; Lihong Liang; Kai Liao; Hao Zeng; Xue Yang; Xiaoran Wang; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, stress, autophagy, western blotting, impairment
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):23. https://doi.org/10.1167/iovs.66.5.23

Includes: Supplemental Content

Retina May 2025

A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts

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Jialiang Yang; Haiping Wu; Qi Li; Jiaxin Guo; Jialin Yao; Shengliu Pan; Xiawei Wu; Haotian Huang; Runfang Chen; Junnian Chen; Yubin Wang; Yue Peng; Fuhua Wu; Jing Hu
TAGS: mice, patient isolation, retina, social isolation, phosphate-buffered saline, personal integrity
Trans. Vis. Sci. Tech.. 2025; 14(5):14. https://doi.org/10.1167/tvst.14.5.14

Includes: Multimedia, Supplemental Content

Glaucoma May 2025

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

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Sowjanya Gowrisankaran; Ashkan Abbasi; Xubo Song; Joel S. Schuman; Gadi Wollstein; Bhavna J. Antony; Hiroshi Ishikawa
TAGS: glaucoma, optic disk, retinal nerve fiber layer, retinal vessels
Trans. Vis. Sci. Tech.. 2025; 14(5):13. https://doi.org/10.1167/tvst.14.5.13

Clinical and Epidemiologic Research May 2025

Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight

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Charles Bélanger Nzakimuena; Marissé Masís Solano; Rémy Marcotte-Collard; Mark Richard Lesk; Santiago Costantino
TAGS: choroid, space flight, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):17. https://doi.org/10.1167/iovs.66.5.17

Includes: Supplemental Content

Retina May 2025

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

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Xianyang Liu; Hangjia Zuo; Chao Wu; Na Li; Qian Zhou; Fan Cao; Baorui Chu; Shuhao Zeng; Hui Feng; Yakun Wang; Fengyang Lei; Ke Hu; Shengping Hou
TAGS: akt signaling pathway, mice, phosphoinositide 3-kinase, proteins, uveitis, inflammation, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):21. https://doi.org/10.1167/iovs.66.5.21

Includes: Supplemental Content

Lens May 2025

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

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Xi Chen; Chenshuang Li; Jiankui Li; Zaoxia Guo; Siqi Zhang; Chenjun Guo; Hong Yan
TAGS: after-cataract, epithelial to mesenchymal transition, methyltransferase, proteins, rna, thrombospondin 1, western blotting, protein overexpression, polymerase chain reaction, cataract surgery
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):20. https://doi.org/10.1167/iovs.66.5.20

Includes: Supplemental Content

Research Opportunities May 2025

Advancing Toward a World Without Vision Loss From Diabetes: Insights From The Mary Tyler Moore Vision Initiative Symposium 2024 on Curing Vision Loss From Diabetes

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Ward Fickweiler; Konstantina Sampani; Dorene S. Markel; S. Robert Levine; Jennifer K. Sun; Thomas W. Gardner
TAGS: blindness, diabetes mellitus, myopic foveoschisis, vision, medication therapy management, retinal diseases
Trans. Vis. Sci. Tech.. 2025; 14(5):12. https://doi.org/10.1167/tvst.14.5.12

Retina May 2025

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

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Lisa Lombardi; Matthew A. Petoe; Lauren Moussallem; Maria Kolic; Elizabeth K. Baglin; Samuel Stefopoulos; Xerxes Battiwalla; Janine G. Walker; Nick Barnes; Carla J. Abbott; Penelope J. Allen; for the Bionics Institute and Centre for Eye Research Australia Retinal Prosthesis Consortium
TAGS: brca2 gene, congenital heart disease, coronary arteriosclerosis, coronary heart disease, face, flavin-adenine dinucleotide, prostheses, psen1 gene, second language, second lumbar vertebra
Trans. Vis. Sci. Tech.. 2025; 14(5):11. https://doi.org/10.1167/tvst.14.5.11

Biochemistry and Molecular Biology May 2025

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

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Binyu Wen; Hangyu Li; Hui Tao; Hong Ren; Bosheng Ma; Mengdi Shi; Shen Chen; Jiaqi Du; Ziyi Cai; Jing Zhang; Dongshi Guan; Zhihong Deng
TAGS: caviidae, collagen, gelatinase a, myopia, sclera, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):19. https://doi.org/10.1167/iovs.66.5.19

Includes: Supplemental Content

Retina May 2025

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda
TAGS: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone, fovea centralis, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):18. https://doi.org/10.1167/iovs.66.5.18

Includes: Supplemental Content

Retina May 2025

Comparing the Efficiency of Fluid Infusion Systems for Pars Plana Vitrectomy

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Tommaso Rossi; Giorgio Querzoli; Giov Battista Angelini; Veronica Santoro; Camilla Pellizzaro; David H. Steel; Mariacristina Parravano; Mario R. Romano
TAGS: infusion procedures, infusion sets, vitrectomy, trocar, pars plana
Trans. Vis. Sci. Tech.. 2025; 14(5):10. https://doi.org/10.1167/tvst.14.5.10

Retina May 2025

Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation

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Akira Machida; Keiji Suzuki; Takafumi Nakayama; Sugao Miyagi; Yuki Maekawa; Ryuya Murakami; Masafumi Uematsu; Takashi Kitaoka; Akio Oishi
TAGS: choroidal neovascularization, lasers, inflammation, nlr family, pyrin domain-containing 3 protein, agonists, uveitis, liraglutide, glucagon-like peptide-1 agonists, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):15. https://doi.org/10.1167/iovs.66.5.15

Includes: Supplemental Content

Retina May 2025

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

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Chengming Chen; Yanyan Lan; Weiming Yan; Xiaohong Zhang; Tian Li; Jing Han
TAGS: age-related macular degeneration, metabolites, plasma, proteins, european continental ancestry group
Trans. Vis. Sci. Tech.. 2025; 14(5):8. https://doi.org/10.1167/tvst.14.5.8

Includes: Supplemental Content

Article May 2025

Eye-movement patterns for perceiving bistable figures

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Yi-Hsuan Hsu; Chien-Chung Chen
TAGS: ducks, eye movement, oryctolagus cuniculus, perception, eye fixation, eye
Journal of Vision. 2025; 25(6):3. https://doi.org/10.1167/jov.25.6.3

Methods May 2025

Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation

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Thales A. C. de Guimaraes; Angelos Kalitzeos; James Bainbridge; Michel Michaelides
TAGS: eccentric fixation, eye
Trans. Vis. Sci. Tech.. 2025; 14(5):9. https://doi.org/10.1167/tvst.14.5.9

Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Retina May 2025

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

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Alexander Kai Thomsen; Maria Abildgaard Steffensen; Amalie Thomsen Nielsen; Henrik Vorum; Bent Honoré; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: age-related macular degeneration, chemokines, treatment outcome, chemokine receptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):14. https://doi.org/10.1167/iovs.66.5.14

Includes: Supplemental Content

Cornea May 2025

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

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Xujiao Zhou; Yuqing Wu; Yirou Zhang; Binbin Chu; Kan Yang; Jiaxu Hong; Yao He
TAGS: agonists, cornea, dry eye syndromes, inflammation, macrophages, neuroinflammatory diseases, nicotinic receptors, linear gingival erythema, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):13. https://doi.org/10.1167/iovs.66.5.13

Includes: Supplemental Content

Glaucoma May 2025

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

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Yu-Ting Tsao; Hung-Chi Chen; Yi-Jen Hsueh; Yu-Chun Cheng; Eugene Yu-Chuan Kang; Chu-Yen Huang; Yung-Sung Lee
TAGS: antioxidants, aqueous humor, glaucoma, intraocular pressure, teller acuity cards, total arterial compliance, trigeminal autonomic cephalalgias, prospective studies, drug usage
Trans. Vis. Sci. Tech.. 2025; 14(5):7. https://doi.org/10.1167/tvst.14.5.7

Includes: Supplemental Content

Artificial Intelligence May 2025

High-Accuracy Digitization of Humphrey Visual Field Reports Using Convolutional Neural Networks

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Shian-Sen Shie; Wei-Wen Su
TAGS: convolutional neural networks, humphrey visual field plot, metadata, training, visual fields, datasets, generalization (psychology)
Trans. Vis. Sci. Tech.. 2025; 14(5):6. https://doi.org/10.1167/tvst.14.5.6

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Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

Advancing Toward a World Without Vision Loss From Diabetes: Insights From The Mary Tyler Moore Vision Initiative Symposium 2024 on Curing Vision Loss From Diabetes

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

Comparing the Efficiency of Fluid Infusion Systems for Pars Plana Vitrectomy

Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

Eye-movement patterns for perceiving bistable figures

Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

Aqueous Humor Antioxidants in Glaucoma: Correlations With Subtypes, Intraocular Pressure, and Medication Use—A Prospective Study

High-Accuracy Digitization of Humphrey Visual Field Reports Using Convolutional Neural Networks

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