Genetics

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Biochemistry and Molecular Biology May 2025

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Xiaotong Sha; Anqi Sun; Huijing Ye; Huasheng Yang
TAGS: fibrosis, protein glutamine gamma glutamyltransferase 2, autocrine, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):22. https://doi.org/10.1167/iovs.66.5.22

Includes: Supplemental Content

Retina May 2025

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

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Xianyang Liu; Hangjia Zuo; Chao Wu; Na Li; Qian Zhou; Fan Cao; Baorui Chu; Shuhao Zeng; Hui Feng; Yakun Wang; Fengyang Lei; Ke Hu; Shengping Hou
TAGS: akt signaling pathway, mice, phosphoinositide 3-kinase, proteins, uveitis, inflammation, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):21. https://doi.org/10.1167/iovs.66.5.21

Includes: Supplemental Content

Retina May 2025

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

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Lisa Lombardi; Matthew A. Petoe; Lauren Moussallem; Maria Kolic; Elizabeth K. Baglin; Samuel Stefopoulos; Xerxes Battiwalla; Janine G. Walker; Nick Barnes; Carla J. Abbott; Penelope J. Allen; for the Bionics Institute and Centre for Eye Research Australia Retinal Prosthesis Consortium
TAGS: brca2 gene, congenital heart disease, coronary arteriosclerosis, coronary heart disease, face, flavin-adenine dinucleotide, prostheses, psen1 gene, second language, second lumbar vertebra
Trans. Vis. Sci. Tech.. 2025; 14(5):11. https://doi.org/10.1167/tvst.14.5.11

Biochemistry and Molecular Biology May 2025

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

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Binyu Wen; Hangyu Li; Hui Tao; Hong Ren; Bosheng Ma; Mengdi Shi; Shen Chen; Jiaqi Du; Ziyi Cai; Jing Zhang; Dongshi Guan; Zhihong Deng
TAGS: caviidae, collagen, gelatinase a, myopia, sclera, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):19. https://doi.org/10.1167/iovs.66.5.19

Includes: Supplemental Content

Retina May 2025

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda
TAGS: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone, fovea centralis, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):18. https://doi.org/10.1167/iovs.66.5.18

Includes: Supplemental Content

Retina May 2025

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

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Chengming Chen; Yanyan Lan; Weiming Yan; Xiaohong Zhang; Tian Li; Jing Han
TAGS: age-related macular degeneration, metabolites, plasma, proteins, european continental ancestry group
Trans. Vis. Sci. Tech.. 2025; 14(5):8. https://doi.org/10.1167/tvst.14.5.8

Includes: Supplemental Content

Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Retina May 2025

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

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Alexander Kai Thomsen; Maria Abildgaard Steffensen; Amalie Thomsen Nielsen; Henrik Vorum; Bent Honoré; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: age-related macular degeneration, chemokines, treatment outcome, chemokine receptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):14. https://doi.org/10.1167/iovs.66.5.14

Includes: Supplemental Content

Cornea May 2025

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

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Xujiao Zhou; Yuqing Wu; Yirou Zhang; Binbin Chu; Kan Yang; Jiaxu Hong; Yao He
TAGS: agonists, cornea, dry eye syndromes, inflammation, macrophages, neuroinflammatory diseases, nicotinic receptors, linear gingival erythema, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):13. https://doi.org/10.1167/iovs.66.5.13

Includes: Supplemental Content

Genetics May 2025

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

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Andrew Briere; Peter Vo; Benjamin Yang; David Adams; Takanori Amano; Oana Amarie; Zorana Berberovic; Lynette Bower; Steve D. M. Brown; Samantha Burrill; Soo Young Cho; Sharon Clementson-Mobbs; Abigail D'souza; Mohammad Eskandarian; Ann M. Flenniken; Helmut Fuchs; Valerie Gailus-Durner; Yann Hérault; Martin Hrabe de Angelis; Shundan Jin; Russell Joynson; Yeon Kyung Kang; Haerim Kim; Hiroshi Masuya; Hamid Meziane; Ki-Hoan Nam; Hyuna Noh; Lauryl M. J. Nutter; Marcela Palkova; Jan Prochazka; Miles Joseph Raishbrook; Fabrice Riet; Jason Salazar; Radislav Sedlacek; Mohammed Selloum; Kyoung Yul Seo; Je Kyung Seong; Hae-Sol Shin; Toshihiko Shiroishi; Michelle Stewart; Karen Svenson; Masaru Tamura; Heather Tolentino; Sara Wells; Wolfgang Wurst; Atsushi Yoshiki; Louise Lanoue; K. C. Kent Lloyd; Brian C. Leonard; Michel J. Roux; Colin McKerlie; Ala Moshiri; for The International Mouse Phenotyping Consortium
TAGS: genes, hereditary corneal dystrophy, mice, knockout, phenotype determination, proteins, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):7. https://doi.org/10.1167/iovs.66.5.7

Includes: Supplemental Content

Cornea May 2025

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization

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Hokoru Yoshioka; Mayumi Ueta; Seiichi Yokoo; Norihiko Yokoi; Katsura Mizushima; Yuji Naito; Shigeru Kinoshita; Chie Sotozono
TAGS: conjunctival epithelial cells, keratinization, retinoic acid receptor, retinoic acid receptor alpha, signal transduction, tretinoin, vitamin a, polymerase chain reaction, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):6. https://doi.org/10.1167/iovs.66.5.6

Includes: Supplemental Content

Lens May 2025

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

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Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim
TAGS: after-cataract, cataract, cataract, senile, epithelial cells, genes, lens, crystalline, rna-seq, steroids, vitrectomy, rna
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):4. https://doi.org/10.1167/iovs.66.5.4

Includes: Supplemental Content

Retina May 2025

Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy

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Yaqi Bai; Yujia Xi; Chenwei Gui; Guohai Huang; Guohong Zhou
TAGS: diabetic retinopathy, genetics, mechanistic target of rapamycin complex 1, proteins
Trans. Vis. Sci. Tech.. 2025; 14(5):4. https://doi.org/10.1167/tvst.14.5.4

Includes: Supplemental Content

Biochemistry and Molecular Biology May 2025

Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy

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Dayoon Cho; Soo Hyun Choi; Jin Sook Yoon; JaeSang Ko
TAGS: cytokine, fibroblasts, inflammation, methyltransferase, niacinamide, pathogenesis, body tissue, western blotting, cyclooxygenase-2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):3. https://doi.org/10.1167/iovs.66.5.3

Includes: Supplemental Content

Refractive Intervention May 2025

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

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Yue Xu; Xing-Xuan Dong; Yun Wang; Xin-Yu Zhuang; Ying-Jie Chen; Xiao-Feng Zhang; Chen-Wei Pan
TAGS: cytokine, mendelian randomization analysis, refractive errors, ciliary motility disorders
Trans. Vis. Sci. Tech.. 2025; 14(5):1. https://doi.org/10.1167/tvst.14.5.1

Includes: Supplemental Content

Retina April 2025

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

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Yijie Yang; Jiawei Shen; Yanting Li; Xinzhu Chen; Gaoqin Liu; Peirong Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, choroid, epithelial to mesenchymal transition, fibrosis, mice, lasers, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):83. https://doi.org/10.1167/iovs.66.4.83

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis

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Francesca Giovannetti; Paola Pontecorvi; Francesca Megiorni; Marta Armentano; Ludovico Alisi; Enrico Romano; Cinzia Marchese; Alessandro Lambiase; Alice Bruscolini
TAGS: dry eye syndromes, micrornas, peeling skin syndrome, systemic scleroderma, sjogren's syndrome, bioinformatics, eye, conjunctiva, molecular profiling
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):80. https://doi.org/10.1167/iovs.66.4.80

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

Multiterminal En Plaque Motor Endplates in Extraocular Muscles Are Conserved Across Vertebrate Species

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Jing-Xia Liu; Abraha Kahsay; Nils Dennhag; Jonas von Hofsten; Fatima Pedrosa Domellöf
TAGS: mice, motor endplate, muscle of orbit, neuromuscular junction, vertebrates, zebrafish, oryctolagus cuniculus, antibodies, muscle
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):77. https://doi.org/10.1167/iovs.66.4.77

Includes: Supplemental Content

Retina April 2025

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease

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Jeroen A. A. H. Pas; Catherina H. Z. Li; Filip Van den Broeck; Patty P. A. Dhooge; Julie De Zaeytijd; Rob W. J. Collin; Bart P. Leroy; Carel B. Hoyng
TAGS: age of onset, atrophy, abca4 gene, stargardt's disease, mutation, growth rate
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):76. https://doi.org/10.1167/iovs.66.4.76

Includes: Supplemental Content

Retina April 2025

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

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Toshiaki Abe; Reiko Daigaku; Xie Yuting; Yasukazu Daigaku; Nobuhiro Nagai; Hirokazu Kaji; Aya Katsuyama; Yuki Katsukura; Yasuko Izumida; Atsuko Suzuki; Shinji Yamada; Yao-Wen Chang; Keiko Terada; Sei-ichi Ishiguro; Noriko Osumi; Hiroshi Kunikata; Toru Nakazawa
TAGS: hmgn1 protein, mice, proteins, mobility, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):70. https://doi.org/10.1167/iovs.66.4.70

Includes: Supplemental Content

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Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts

Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy

Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy

Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

Conjunctival MicroRNA Expression Signature in Primary Sjögren's Syndrome Dry Eye: A NanoString-Based Bioinformatic Analysis

Multiterminal En Plaque Motor Endplates in Extraocular Muscles Are Conserved Across Vertebrate Species

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

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