Nanotechnology and Regenerative Medicine

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Retinal Cell Biology October 2024

Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation

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Ryutaro Akiba; Hung-Ya Tu; Tomoyo Hashiguchi; Yoshiko Takahashi; Kiminori Toyooka; Yoshihiko Tsukamoto; Takayuki Baba; Masayo Takahashi; Michiko Mandai
TAGS: synapses, tissue transplants, transplantation, photoreceptors, shape, retinal bipolar cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):8. https://doi.org/10.1167/iovs.65.12.8

Includes: Supplemental Content

Retina September 2024

Establishing Clinical Trial Endpoints in Selecting Patients for RPGR Retinal Gene Therapy

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Evita Evangelia Christou; Amandeep S. Josan; Jasmina Cehajic-Kapetanovic; Robert E. MacLaren
TAGS: gene therapy, retinitis pigmentosa, surrogate endpoints
Trans. Vis. Sci. Tech.. 2024; 13(9):18. https://doi.org/10.1167/tvst.13.9.18

Retinal Cell Biology September 2024

iPSC-Derived LCHADD Retinal Pigment Epithelial Cells Are Susceptible to Lipid Peroxidation and Rescued by Transfection of a Wildtype AAV- HADHA Vector

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Tiffany DeVine; Gabriela Elizondo; Garen Gaston; Shannon J. Babcock; Dietrich Matern; Mikhail S. Shchepinov; Mark E. Pennesi; Cary O. Harding; Melanie B. Gillingham
TAGS: disease vectors, induced pluripotent stem cells, ketones, lipid peroxidation, retinal pigment cell, spatial vectors, transfection, fatty acid oxidation, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):22. https://doi.org/10.1167/iovs.65.11.22

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2024

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

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Saira Rizwan; Beverly Toothman; Bo Li; Abbi L. Engel; Rayne R. Lim; Sheldon Niernberger; Jinyu Lu; Cloe Ratliff; Yinxiao Xiang; Mark Eminhizer; Jennifer R. Chao; Jianhai Du
TAGS: glutamine, nutrients, phenotype determination, retinal pigment cell, sugars, induced pluripotent stem cells, amino acids
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):5. https://doi.org/10.1167/iovs.65.11.5

Includes: Supplemental Content

Cornea & External Disease September 2024

The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up

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Ángel Nava-Castañeda; Lilia Garnica-Hayashi; Noé Santiago-Rea; Edric González-Mondragón; Beatriz Buentello-Volante; Fátima Sofía Magaña-Guerrero; Yonathan Garfias
TAGS: conjunctiva, mucins, pterygium, transplantation, transplantation, autologous, follow-up, amnion, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2024; 13(9):10. https://doi.org/10.1167/tvst.13.9.10

New Developments in Vision Research August 2024

Report From the Second Global Scientific Conference on Clinical Trial Design and Outcome Measures for RDH12 -Associated Inherited Retinal Degeneration

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Silvia Cerolini; Jean Bennett; Bart P. Leroy; Todd Durham; Courtney Coates; Mathew T. Pletcher; Sue Lacey; Tomas S. Aleman
TAGS: gene therapy, outcome measures, retinal degeneration, science, vision
Trans. Vis. Sci. Tech.. 2024; 13(8):17. https://doi.org/10.1167/tvst.13.8.17

Retina August 2024

IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration

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Hong Zhou; Yan Liu; Tian Zhou; Ziqi Yang; Biyan Ni; Yang Zhou; Huiyi Xu; Xiaojing Lin; Shiya Lin; Chang He; Xialin Liu
TAGS: exosomes, interleukin-23, mesenchymal stem cells, micrornas, neuroprotective effect, retinal degeneration, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):8. https://doi.org/10.1167/iovs.65.10.8

Includes: Supplemental Content

Clinical Trials July 2024

Utility of a Model to Predict Endothelial Cell Density of Donor Corneas to Determine Suitability for Transplantation

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Julia B. Bu; Stephanie D. Grabitz; Franziska Schön; Melissa Apel; Tobias Pusch; Adrian Gericke; Alicia Poplawski; Norbert Pfeiffer; Joanna Wasielica-Poslednik
TAGS: cornea, donors, endothelial cells, transplantation
Trans. Vis. Sci. Tech.. 2024; 13(7):21. https://doi.org/10.1167/tvst.13.7.21

Includes: Supplemental Content

Retina July 2024

Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues

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Cheri Z. Chambers; Gillian L. Soo; Abbi L. Engel; Ian A. Glass; the Birth Defects Research Laboratory (BDRL); Andrea Frassetto; Paolo G. V. Martini; Timothy J. Cherry
TAGS: lipid nanoparticles, mice, retina, rna, messenger, lipids, body tissue
Trans. Vis. Sci. Tech.. 2024; 13(7):7. https://doi.org/10.1167/tvst.13.7.7

Includes: Supplemental Content

Cornea June 2024

Mitochondria Transplantation Promotes Corneal Epithelial Wound Healing

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Daniel Raz; Keren Ben-Yaakov; Michal Levi; Marina Bertolin; Stefano Ferrari; Diego Ponzin; Massimo Busin; Hana Leiba; Arie L. Marcovich; Avital Eisenberg-Lerner; Ziv Rotfogel
TAGS: cornea, mitochondria, transplantation, wound healing, epithelium, mice, alkalies
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):14. https://doi.org/10.1167/iovs.65.6.14

Retina June 2024

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

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Ricarda Jendritza; Krunoslav Stingl; Torsten Strasser; Ronja Jung; Felix Tonagel; Paul Richter; Anton Sonntag; Tobias Peters; Helmut Wilhelm; Barbara Wilhelm; Carina Kelbsch
TAGS: biological markers, cardiac progenitor cells, cohort studies, pupil, pupil light reflex, retinal cone, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):3. https://doi.org/10.1167/iovs.65.6.3

Retina May 2024

Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells

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Younghoon Park; Jaewoo Shin; Junwon Park; Seulbi Kim; Ji Hun Park; Jaeheung Kim; Chang Seok Kim; Jin Woo Chang; Carol Schuurmans; Isabelle Aubert; Won Seok Chang; Kyungsik Eom
TAGS: dextran, gold, nanoparticles, retina, retinal ganglion cells, ultrasonography, diagnostic imaging, photons, body tissue
Trans. Vis. Sci. Tech.. 2024; 13(5):5. https://doi.org/10.1167/tvst.13.5.5

Includes: Supplemental Content

Cornea May 2024

The Role of SLIT3–ROBO4 Signaling in Endoplasmic Reticulum Stress–Induced Delayed Corneal Epithelial and Nerve Regeneration

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Rong Chen; Yao Wang; Zhenzhen Zhang; Xiaolei Wang; Ya Li; Min Wang; Huifeng Wang; Muchen Dong; Qingjun Zhou; Lingling Yang
TAGS: cornea, epithelium, mice, nerve regeneration, stress, signal transduction, endoplasmic reticulum, wound healing
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):8. https://doi.org/10.1167/iovs.65.5.8

Includes: Supplemental Content

Retinal Cell Biology April 2024

CFH Haploinsufficiency and Complement Alterations in Early-Onset Macular Degeneration

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Rayne R. Lim; Sharlene Shirali; Jessica Rowlan; Abbi L. Engel; Marcos Nazario,, Jr.; Kelie Gonzalez; Aspen Tong; Jay Neitz; Maureen Neitz; Jennifer R. Chao
TAGS: complement system proteins, macular degeneration, retinal pigment cell, haploinsufficiency, proteins, induced pluripotent stem cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):43. https://doi.org/10.1167/iovs.65.4.43

Includes: Supplemental Content

Cornea March 2024

Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway

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Shuting Liu; Hua Chen; Huatao Xie; Xin Liu; Mingchang Zhang
TAGS: chronic exertional compartment syndrome, cornea, corneal endothelium, oryctolagus cuniculus, scirrhous adenocarcinoma
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):15. https://doi.org/10.1167/iovs.65.3.15

Includes: Supplemental Content

Retina February 2024

Chorioretinal Atrophy Growth After Voretigene Neparvovec Retinotopically Is Connected to Retinal Functional Rescue

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Krunoslav Stingl; Melanie Kempf; Ronja Jung; Katarina Stingl
TAGS: atrophy, chorioretinal atrophy, gene therapy, rod photoreceptors, voretigene neparvovec
Trans. Vis. Sci. Tech.. 2024; 13(2):13. https://doi.org/10.1167/tvst.13.2.13

Cornea January 2024

Effector T Cells Promote Fibrosis in Corneal Transplantation Failure

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Shudan Wang; Sharad K. Mittal; Seokjoo Lee; Antonio Esquivel Herrera; Mark Krauthammer; Elsayed Elbasiony; Tomas Blanco; Hamid Alemi; Hayate Nakagawa; Sunil K. Chauhan; Reza Dana; Thomas H. Dohlman
TAGS: fibrosis, keratoplasty, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):40. https://doi.org/10.1167/iovs.65.1.40

Includes: Supplemental Content

Anatomy and Pathology/Oncology December 2023

The Use of rAAV2-RB1–Mediated Gene Therapy in Retinoblastoma

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Hanhan Shi; Xiaoyu He; Zhi Yang; Qili Liao; Jing Ruan; Shengfang Ge; Peiwei Chai; Renbing Jia; Jiayan Fan; Xuyang Wen; Xianqun Fan
TAGS: gene therapy, retinoblastoma, neoplasms, mice, intravitreal injections, western blotting, spatial vectors
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):31. https://doi.org/10.1167/iovs.64.15.31

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract December 2023

Poster Session II: Intravitreal gene therapy in primate reaches extrafoveal cones

Briyana Bembry - Colegrove; Michelle Giarmarco; Rachel Barborek; Jessica Rowlan; James Kuchenbecker; Dragos Rezeanu; Jay Neitz; Maureen Neitz
TAGS: gene therapy, posters, primates, retinal cone
Journal of Vision. 2023; 23(15):66. https://doi.org/10.1167/jov.23.15.66

Optica Fall Vision Meeting Abstract December 2023

Invited Session II: Retinal remodeling and regeneration: Insights into retinal cell replacement: Optimising photoreceptor and RPE transplantation

Karen Tessmer; Sylvia Jane Gasparini; Juliane Hammer; Trishla Adhikari; Klara Schmidtke; Sebastian Knöbel; Marius Ader
TAGS: photoreceptors, transplantation
Journal of Vision. 2023; 23(15):10. https://doi.org/10.1167/jov.23.15.10

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Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation

Establishing Clinical Trial Endpoints in Selecting Patients for RPGR Retinal Gene Therapy

iPSC-Derived LCHADD Retinal Pigment Epithelial Cells Are Susceptible to Lipid Peroxidation and Rescued by Transfection of a Wildtype AAV- HADHA Vector

Metabolic Phenotyping of Healthy and Diseased Human RPE Cells

The Effect of Amniotic Membrane Transplantation or Conjunctival Autografts on the Tear Mucins MUC5A and MUC2 After Pterygium Resection: A Six-Month Follow-Up

Report From the Second Global Scientific Conference on Clinical Trial Design and Outcome Measures for RDH12 -Associated Inherited Retinal Degeneration

IL-23 Priming Enhances the Neuroprotective Effects of MSC-Derived Exosomes in Treating Retinal Degeneration

Utility of a Model to Predict Endothelial Cell Density of Donor Corneas to Determine Suitability for Transplantation

Lipid Nanoparticle-Mediated Delivery of mRNA Into the Mouse and Human Retina and Other Ocular Tissues

Mitochondria Transplantation Promotes Corneal Epithelial Wound Healing

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells

The Role of SLIT3–ROBO4 Signaling in Endoplasmic Reticulum Stress–Induced Delayed Corneal Epithelial and Nerve Regeneration

CFH Haploinsufficiency and Complement Alterations in Early-Onset Macular Degeneration

Substrate Stiffness Modulates Stemness and Differentiation of Rabbit Corneal Endothelium Through the Paxillin–YAP Pathway

Chorioretinal Atrophy Growth After Voretigene Neparvovec Retinotopically Is Connected to Retinal Functional Rescue

Effector T Cells Promote Fibrosis in Corneal Transplantation Failure

The Use of rAAV2-RB1–Mediated Gene Therapy in Retinoblastoma

Poster Session II: Intravitreal gene therapy in primate reaches extrafoveal cones

Invited Session II: Retinal remodeling and regeneration: Insights into retinal cell replacement: Optimising photoreceptor and RPE transplantation

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