Pharmacology

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Article April 2024

An efficient Bayesian observer model of attractive and repulsive temporal context effects when perceiving multistable dot lattices

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Eline Van Geert; Tina Ivančir; Johan Wagemans
TAGS: perception
Journal of Vision. 2024; 24(4):18. https://doi.org/10.1167/jov.24.4.18

Includes: Supplemental Content

Refractive Intervention April 2024

Differential Impact of 0.01% and 0.05% Atropine Eyedrops on Ocular Surface in Young Adults

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Yifan Luo; Ziang Yin; Jiali Zhang; Weijia Wang; Yingying Huang; Xue Li; Hao Chen; Fan Lu; Jinhua Bao
TAGS: atropine, eyedrops, ocular surfaces, young adult
Trans. Vis. Sci. Tech.. 2024; 13(4):22. https://doi.org/10.1167/tvst.13.4.22

Retinal Cell Biology April 2024

Dose-Related Side Effects of Intravitreal Injections of Humanized Anti-Vascular Endothelial Growth Factor in Rats: Glial Cell Reactivity and Retinal Ganglion Cell Loss

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Ana Martínez-Vacas; Johnny Di Pierdomenico; Ana María Gómez-Ramirez; Manuel Vidal-Sanz; María P. Villegas-Pérez; Diego García-Ayuso
TAGS: adverse effects, aflibercept, antibodies, anti-vascular endothelial growth factor therapy, endothelial growth factors, eye, intravitreal injections, mass or substance concentration per volume, neuroglia, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):10. https://doi.org/10.1167/iovs.65.4.10

Includes: Supplemental Content

Retina April 2024

Drug Distribution After Intravitreal Injection: A Mathematical Model

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Alessia Ruffini; Alessia Casalucci; Caterina Cara; C. Ross Ethier; Rodolfo Repetto
TAGS: drug distribution, eye, injections, intravitreal injections, mathematical model, vitreous body, intraocular pressure, fluid flow, biological transport
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):9. https://doi.org/10.1167/iovs.65.4.9

Article April 2024

Why did Rubens add a parrot to Titian's The Fall of Man ? A pictorial manipulation of joint attention

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Robert G. Alexander; Ashwin Venkatakrishnan; Jordi Chanovas; Sophie Ferguson; Stephen L. Macknik; Susana Martinez-Conde
TAGS: face, gaze, joint engagement, methylenedioxyethylamphetamine, paintings, eye movement
Journal of Vision. 2024; 24(4):1. https://doi.org/10.1167/jov.24.4.1

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2024

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β

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Christopher M. McCurry; Siddharth Sunilkumar; Sandeep M. Subrahmanian; Esma I. Yerlikaya; Allyson L. Toro; Ashley M. VanCleave; Shaunaci A. Stevens; Alistair J. Barber; Jeffery M. Sundstrom; Michael D. Dennis
TAGS: diabetes mellitus, mice, nlr family, pyrin domain-containing 3 protein, retina, inflammasomes, hyperglycemic agents
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):34. https://doi.org/10.1167/iovs.65.3.34

Includes: Supplemental Content

Genetics March 2024

High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma

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Bhavana Kunisetty; Bailey A. Martin-Giacalone; Xiaonan Zhao; Pamela N. Luna; Brian P. Brooks; Robert B. Hufnagel; Chad A. Shaw; Jill A. Rosenfeld; A. J. Agopian; Philip J. Lupo; Daryl A. Scott
TAGS: cauda equina syndrome, cesium, complement membrane attack complex, genes, mac protocol, macao, mdc protocol, microphthalmos, mid upper arm circumference, minimum alveolar concentration
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):25. https://doi.org/10.1167/iovs.65.3.25

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2024

The Association Between Metformin Use and New-Onset ICD Coding of Geographic Atrophy

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John Moir; Max J. Hyman; Reem Gonnah; Andrea Flores; Seenu M. Hariprasad; Dimitra Skondra
TAGS: age-related macular degeneration, nonexudative, metformin, diabetes mellitus, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):23. https://doi.org/10.1167/iovs.65.3.23

Includes: Supplemental Content

Anatomy and Pathology/Oncology February 2024

Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior

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Vera E. Pawlik; Svenja R. Sonntag; Salvatore Grisanti; Aysegül Tura; Vinodh Kakkassery; Mahdy Ranjbar
TAGS: aflibercept, angiogenesis inhibitors, bevacizumab, intraocular melanoma, nintedanib, ranibizumab, vascular endothelial growth factor a, cell lines, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):30. https://doi.org/10.1167/iovs.65.2.30

Includes: Supplemental Content

Physiology and Pharmacology February 2024

Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice

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Preston E. Girardot; Xian Zhang; Nan Zhang; Kevin J. Donaldson; Micah A. Chrenek; Jana T. Sellers; Andrew J. Feola; Jack Papania; John M. Nickerson; Nieraj Jain; Jeffrey H. Boatright
TAGS: mice, pentosan polysulfate sodium, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):28. https://doi.org/10.1167/iovs.65.2.28

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology February 2024

In Vivo Imaging of Secondary Neurodegeneration Associated With Phosphatidylserine Externalization Along Axotomized Axons

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Fan Yang; Mohammadali Almasieh; Leonard A. Levin
TAGS: axon, axotomy, diagnostic imaging, nerve degeneration, phosphatidylserines, wounds and injuries, lasers, retrograde degeneration
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):24. https://doi.org/10.1167/iovs.65.2.24

Includes: Supplemental Content

Cornea & External Disease February 2024

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

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Filippo Bonelli; Fabiola Campestre; Romina Mayra Lasagni Vitar; Ibrahim Halil Demirsoy; Philippe Fonteyne; Giulio Ferrari
TAGS: aprepitant, cornea, pain, signs and symptoms, dry eye syndromes
Trans. Vis. Sci. Tech.. 2024; 13(2):9. https://doi.org/10.1167/tvst.13.2.9

Includes: Supplemental Content

Retina January 2024

Response of Human Retinal Microvascular Endothelial Cells to Influenza A (H1N1) Infection and the Underlying Molecular Mechanism

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Shuo Yang; Zixin Fan; Xiaofeng Lu; Hui Liu; Ziying Zhou; Hui Qi; Jian Zeng; Mianying Zheng; Xuan Zou; Shisong Fang; Guoming Zhang
TAGS: infections, influenza a virus, h1n1 subtype, swine influenza, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):38. https://doi.org/10.1167/iovs.65.1.38

Retina January 2024

Factors Associated With Intraocular Inflammation in Neovascular Age-Related Macular Degeneration Patients Treated With Brolucizumab

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Yuto Hashimoto; Satoru Inoda; Hidenori Takahashi; Ryota Takahashi; Hana Yoshida; Yujiro Fujino; Shinichi Sakamoto; Hidetoshi Kawashima; Yasuo Yanagi
TAGS: brolucizumab, exudative age-related macular degeneration, uveitis, aqueous humor, proteins, injections, biological markers
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):8. https://doi.org/10.1167/iovs.65.1.8

Glaucoma December 2023

Resveratrol Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting the NLRP3/Gasdermin D/Caspase-1/Interleukin-1β Pyroptosis Pathway

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Zhi Xie; Qian Ying; Hongdou Luo; Mengqi Qin; Yulian Pang; Haijian Hu; Jing Zhong; Yuning Song; Ziqiao Zhang; Xu Zhang
TAGS: caspase-1, nlr family, pyrin domain-containing 3 protein, pyroptosis, resveratrol, wounds and injuries, retina, mice, reperfusion injury, interleukins
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):28. https://doi.org/10.1167/iovs.64.15.28

Retina December 2023

Intravitreal Brolucizumab for Pachychoroid Neovasculopathy Associated With Chronic Central Serous Chorioretinopathy

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Marianna Carosielli; Adriano Carnevali; Matteo Fallico; Enza Pirozzi; Flavia Chiosi; Argyrios Chronopoulos; Pasquale Cucciniello; Marzia Affatato; Giuseppe Rapino; Roberto dell'Omo; on behalf of the BROCS study group, BROCS (BROlucizumab for the treatment of Central Serous chorioretinopathy) study group†
TAGS: brolucizumab, central serous chorioretinopathy, eye, injections, anti-vascular endothelial growth factor therapy
Trans. Vis. Sci. Tech.. 2023; 12(12):17. https://doi.org/10.1167/tvst.12.12.17

Retina December 2023

Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis

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Jason Y. Zhang; Jason Xiao; Bingqing Xie; Hugo Barba; Michael Boachie-Mensah; Rohan N. Shah; Urooba Nadeem; Melanie Spedale; Nicholas Dylla; Huaiying Lin; Ashley M. Sidebottom; Mark D'Souza; Betty Theriault; Dinanath Sulakhe; Eugene B. Chang; Dimitra Skondra
TAGS: choroidal neovascularization, metformin, retina, mice
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):21. https://doi.org/10.1167/iovs.64.15.21

Includes: Supplemental Content

Retina December 2023

Minocycline and Diacetyl Minocycline Eye Drops Reduce Ocular Neovascularization in Mice

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Joshua O. Willms; Kelly Mitchell; Mayank Shashtri; Olof Sundin; Xiaobo Liu; Praneetha Panthagani; Phat Tran; Stephany Navarro; Colton Sniegowski; Abdul A. Shaik; Tristin Chaudhury; Ted W. Reid; Susan E. Bergeson
TAGS: choroidal neovascularization, eyedrops, mice, minocycline, neovascularization, pathologic, diacetyl
Trans. Vis. Sci. Tech.. 2023; 12(12):10. https://doi.org/10.1167/tvst.12.12.10

Includes: Multimedia, Supplemental Content

Glaucoma December 2023

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells

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Tilahun Ayane Debele; Zachary F. Mount; Yong Yuan; Winston W.-Y. Kao; Yoonjee C. Park
TAGS: actins, collagen, cytotoxicity, dexamethasone, gel, glaucoma, permeability, phenotype, prevention, trabecular meshwork
Trans. Vis. Sci. Tech.. 2023; 12(12):4. https://doi.org/10.1167/tvst.12.12.4

Includes: Supplemental Content

Glaucoma November 2023

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone

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Xiaofeng Zhu; Bei Zeng; Caiqing Wu; Zidong Chen; Minbin Yu; Yangfan Yang
TAGS: fibrosis, intraocular pressure, mice, pirfenidone, trabecular meshwork, western blotting, cytoskeleton
Trans. Vis. Sci. Tech.. 2023; 12(11):21. https://doi.org/10.1167/tvst.12.11.21

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An efficient Bayesian observer model of attractive and repulsive temporal context effects when perceiving multistable dot lattices

Differential Impact of 0.01% and 0.05% Atropine Eyedrops on Ocular Surface in Young Adults

Dose-Related Side Effects of Intravitreal Injections of Humanized Anti-Vascular Endothelial Growth Factor in Rats: Glial Cell Reactivity and Retinal Ganglion Cell Loss

Drug Distribution After Intravitreal Injection: A Mathematical Model

Why did Rubens add a parrot to Titian's The Fall of Man ? A pictorial manipulation of joint attention

NLRP3 Inflammasome Priming in the Retina of Diabetic Mice Requires REDD1-Dependent Activation of GSK3β

High Clinical Exome Sequencing Diagnostic Rates and Novel Phenotypic Expansions for Nonisolated Microphthalmia, Anophthalmia, and Coloboma

The Association Between Metformin Use and New-Onset ICD Coding of Geographic Atrophy

Impact of Nintedanib and Anti-Angiogenic Agents on Uveal Melanoma Cell Behavior

Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice

In Vivo Imaging of Secondary Neurodegeneration Associated With Phosphatidylserine Externalization Along Axotomized Axons

Aprepitant Restores Corneal Sensitivity and Reduces Pain in DED

Response of Human Retinal Microvascular Endothelial Cells to Influenza A (H1N1) Infection and the Underlying Molecular Mechanism

Factors Associated With Intraocular Inflammation in Neovascular Age-Related Macular Degeneration Patients Treated With Brolucizumab

Resveratrol Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting the NLRP3/Gasdermin D/Caspase-1/Interleukin-1β Pyroptosis Pathway

Intravitreal Brolucizumab for Pachychoroid Neovasculopathy Associated With Chronic Central Serous Chorioretinopathy

Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis

Minocycline and Diacetyl Minocycline Eye Drops Reduce Ocular Neovascularization in Mice

The Effects of ROCK Inhibitor on Prevention of Dexamethasone-Induced Glaucoma Phenotype in Human Trabecular Meshwork Cells

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone

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