Retina

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Retina May 2025

A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts

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Jialiang Yang; Haiping Wu; Qi Li; Jiaxin Guo; Jialin Yao; Shengliu Pan; Xiawei Wu; Haotian Huang; Runfang Chen; Junnian Chen; Yubin Wang; Yue Peng; Fuhua Wu; Jing Hu
TAGS: mice, patient isolation, retina, social isolation, phosphate-buffered saline, personal integrity
Trans. Vis. Sci. Tech.. 2025; 14(5):14. https://doi.org/10.1167/tvst.14.5.14

Includes: Multimedia, Supplemental Content

Glaucoma May 2025

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

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Sowjanya Gowrisankaran; Ashkan Abbasi; Xubo Song; Joel S. Schuman; Gadi Wollstein; Bhavna J. Antony; Hiroshi Ishikawa
TAGS: glaucoma, optic disk, retinal nerve fiber layer, retinal vessels
Trans. Vis. Sci. Tech.. 2025; 14(5):13. https://doi.org/10.1167/tvst.14.5.13

Retina May 2025

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

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Xianyang Liu; Hangjia Zuo; Chao Wu; Na Li; Qian Zhou; Fan Cao; Baorui Chu; Shuhao Zeng; Hui Feng; Yakun Wang; Fengyang Lei; Ke Hu; Shengping Hou
TAGS: akt signaling pathway, mice, phosphoinositide 3-kinase, proteins, uveitis, inflammation, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):21. https://doi.org/10.1167/iovs.66.5.21

Includes: Supplemental Content

Research Opportunities May 2025

Advancing Toward a World Without Vision Loss From Diabetes: Insights From The Mary Tyler Moore Vision Initiative Symposium 2024 on Curing Vision Loss From Diabetes

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Ward Fickweiler; Konstantina Sampani; Dorene S. Markel; S. Robert Levine; Jennifer K. Sun; Thomas W. Gardner
TAGS: blindness, diabetes mellitus, myopic foveoschisis, vision, medication therapy management, retinal diseases
Trans. Vis. Sci. Tech.. 2025; 14(5):12. https://doi.org/10.1167/tvst.14.5.12

Retina May 2025

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

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Lisa Lombardi; Matthew A. Petoe; Lauren Moussallem; Maria Kolic; Elizabeth K. Baglin; Samuel Stefopoulos; Xerxes Battiwalla; Janine G. Walker; Nick Barnes; Carla J. Abbott; Penelope J. Allen; for the Bionics Institute and Centre for Eye Research Australia Retinal Prosthesis Consortium
TAGS: brca2 gene, congenital heart disease, coronary arteriosclerosis, coronary heart disease, face, flavin-adenine dinucleotide, prostheses, psen1 gene, second language, second lumbar vertebra
Trans. Vis. Sci. Tech.. 2025; 14(5):11. https://doi.org/10.1167/tvst.14.5.11

Retina May 2025

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda
TAGS: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone, fovea centralis, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):18. https://doi.org/10.1167/iovs.66.5.18

Includes: Supplemental Content

Retina May 2025

Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation

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Akira Machida; Keiji Suzuki; Takafumi Nakayama; Sugao Miyagi; Yuki Maekawa; Ryuya Murakami; Masafumi Uematsu; Takashi Kitaoka; Akio Oishi
TAGS: choroidal neovascularization, lasers, inflammation, nlr family, pyrin domain-containing 3 protein, agonists, uveitis, liraglutide, glucagon-like peptide-1 agonists, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):15. https://doi.org/10.1167/iovs.66.5.15

Includes: Supplemental Content

Retina May 2025

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

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Chengming Chen; Yanyan Lan; Weiming Yan; Xiaohong Zhang; Tian Li; Jing Han
TAGS: age-related macular degeneration, metabolites, plasma, proteins, european continental ancestry group
Trans. Vis. Sci. Tech.. 2025; 14(5):8. https://doi.org/10.1167/tvst.14.5.8

Includes: Supplemental Content

Methods May 2025

Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation

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Thales A. C. de Guimaraes; Angelos Kalitzeos; James Bainbridge; Michel Michaelides
TAGS: eccentric fixation, eye
Trans. Vis. Sci. Tech.. 2025; 14(5):9. https://doi.org/10.1167/tvst.14.5.9

Retina May 2025

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu
TAGS: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries, up-regulation (physiology), inflammation, lcn2 gene, retina
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):12. https://doi.org/10.1167/iovs.66.5.12

Includes: Supplemental Content

Retina May 2025

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

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Alexander Kai Thomsen; Maria Abildgaard Steffensen; Amalie Thomsen Nielsen; Henrik Vorum; Bent Honoré; Mogens Holst Nissen; Torben Lykke Sørensen
TAGS: age-related macular degeneration, chemokines, treatment outcome, chemokine receptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):14. https://doi.org/10.1167/iovs.66.5.14

Includes: Supplemental Content

Retina May 2025

Aqueous Humor Levels of Vascular Endothelial Growth Factor in Patients With Dry Age-Related Macular Degeneration and Subretinal Drusenoid Deposits

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Eun Gyu Yoon; Ki Tae Nam; Mihyun Choi; Kwang-Eon Choi; Cheolmin Yun
TAGS: age-related macular degeneration, aqueous humor, vascular endothelial growth factor a, drusen
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):10. https://doi.org/10.1167/iovs.66.5.10

Includes: Supplemental Content

Retina May 2025

Long-Term Natural History of Treatment-Naïve Geographic Atrophy in Age-Related Macular Degeneration

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Daniel R. Muth; Laurence Quérat; Abinaya P. Venkataraman; Alberto Dominguez-Vicent; Goran Petrovski; Pete A. Williams; Filippo Locri; Sandrine A. Zweifel; Anders Kvanta
TAGS: age-related macular degeneration, age-related macular degeneration, nonexudative, follow-up, natural history, eye, diagnostic imaging, cohort studies
Trans. Vis. Sci. Tech.. 2025; 14(5):5. https://doi.org/10.1167/tvst.14.5.5

Includes: Supplemental Content

Retina May 2025

Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy

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Yaqi Bai; Yujia Xi; Chenwei Gui; Guohai Huang; Guohong Zhou
TAGS: diabetic retinopathy, genetics, mechanistic target of rapamycin complex 1, proteins
Trans. Vis. Sci. Tech.. 2025; 14(5):4. https://doi.org/10.1167/tvst.14.5.4

Includes: Supplemental Content

Retina May 2025

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion

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Yanying Zhao; Zhengwei Ge; Tingting Guo; Hengwei Liu; Yufan Zhou; Juan Chen; Heping Xu; Zhongping Chen
TAGS: complement 3, lasers, mice, retinal vein occlusion, signal pathway, signal transduction pathways, complement system proteins, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):2. https://doi.org/10.1167/iovs.66.5.2

Includes: Supplemental Content

Retina May 2025

Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes

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Ghazal Valizadeh; Hosein Hoseini-Yazdi; Scott Read; David Alonso-Caneiro; Michael Collins
TAGS: adult, cardiovascular imaging, child, cortical blindness, diagnostic imaging, eye, macula lutea, nose, fovea centralis, choroid
Trans. Vis. Sci. Tech.. 2025; 14(5):3. https://doi.org/10.1167/tvst.14.5.3

Retina April 2025

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

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Yijie Yang; Jiawei Shen; Yanting Li; Xinzhu Chen; Gaoqin Liu; Peirong Lu
TAGS: 1-phosphatidylinositol 3-kinase, akt signaling pathway, choroid, epithelial to mesenchymal transition, fibrosis, mice, lasers, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):83. https://doi.org/10.1167/iovs.66.4.83

Includes: Supplemental Content

Retina April 2025

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease

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Jeroen A. A. H. Pas; Catherina H. Z. Li; Filip Van den Broeck; Patty P. A. Dhooge; Julie De Zaeytijd; Rob W. J. Collin; Bart P. Leroy; Carel B. Hoyng
TAGS: age of onset, atrophy, abca4 gene, stargardt's disease, mutation, growth rate
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):76. https://doi.org/10.1167/iovs.66.4.76

Includes: Supplemental Content

Retina April 2025

Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema

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Biying Chen; Jianing Qiu; Yongan Meng; Youling Liang; Dan Liu; Yuqian Hu; Zhishang Meng; Jing Luo
TAGS: anti-vascular endothelial growth factor therapy, central retinal vein, macular edema, optical coherence tomography, radiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):74. https://doi.org/10.1167/iovs.66.4.74

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

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A Simple and Rapid Method for Simultaneous Isolation of Mouse Retina and RPE Wholemounts

Normative Variability in Retinal Nerve Fiber Layer Thickness: Does It Matter Where the Peaks Are?

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway

Advancing Toward a World Without Vision Loss From Diabetes: Insights From The Mary Tyler Moore Vision Initiative Symposium 2024 on Curing Vision Loss From Diabetes

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases

Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation

Exploring Therapeutic Targets for Age-Related Macular Degeneration From Circulating Proteins to Plasma Metabolites in the European Population

Distance From the Foveal Center: A Method for the Calculation of Eccentric Fixation

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes

Aqueous Humor Levels of Vascular Endothelial Growth Factor in Patients With Dry Age-Related Macular Degeneration and Subretinal Drusenoid Deposits

Long-Term Natural History of Treatment-Naïve Geographic Atrophy in Age-Related Macular Degeneration

Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion

Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes

AZGP1 Attenuates Subretinal Fibrosis and Inhibits Epithelial-Mesenchymal Transition by Blocking the PI3K/AKT Signaling Pathway

Progression of Atrophy as a Function of ABCA4 Variants and Age of Onset in Stargardt Disease

Radiomics Analysis Based on Optical Coherence Tomography to Prognose the Efficacy of Anti-VEGF Therapy of Retinal Vein Occlusion-Related Macular Edema

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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