Vitreous Disorders

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Anatomy and Pathology/Oncology June 2024

Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy

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Anthony B. Daniels; Kamakshi L. Sishtla; Carley M. Bogan; Janene M. Pierce; Sheau-Chiann Chen; Liya Xu; Jesse L. Berry; Timothy W. Corson
TAGS: biological markers, eye, oryctolagus cuniculus, retinoblastoma, seeds, vascular endothelial growth factor a, vitreous body, chemotherapy regimen, aqueous humor, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):18. https://doi.org/10.1167/iovs.65.6.18

Includes: Supplemental Content

Retina May 2024

Complement Cascade 8 - Alpha and Calpain-2 in Extracellular Vesicles of Human Vitreous as Biomarkers of Infectious Endophthalmitis

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Dhanwini Rudraprasad; Velmurugan K; Jayabalan Nirmal; Md. Hasnat Ali; Joveeta Joseph
TAGS: bacterial endophthalmitis, biological markers, calpain, complement system proteins, endophthalmitis, extracellular vesicles, vitreous body
Trans. Vis. Sci. Tech.. 2024; 13(5):14. https://doi.org/10.1167/tvst.13.5.14

Retina May 2024

Light Scattering by Vitreous of Humans With Vision Degrading Myodesopsia From Floaters

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Alba M. Paniagua-Diaz; Justin H. Nguyen; Pablo Artal; Wei Gui; J. Sebag
TAGS: vision, vitreous body, vitreous floaters
Invest. Ophthalmol. Vis. Sci.. 2024; 65(5):20. https://doi.org/10.1167/iovs.65.5.20

Retina April 2024

Short Term Effect of Pre-Operative Anti-VEGF on Angiogenic and Fibrotic Profile of Fibrovascular Membranes of Proliferative Diabetic Retinopathy

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Kaveh Fadakar; Safa Rahmani; Thomas Tedeschi; Jeremy A. Lavine; Amani A. Fawzi
TAGS: angiogenesis, anti-vascular endothelial growth factor therapy, endothelial cells, endothelium, proliferative diabetic retinopathy, tissue membrane, surgical procedures, operative, endothelin-1, gene expression, injections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):37. https://doi.org/10.1167/iovs.65.4.37

Includes: Supplemental Content

Genetics April 2024

Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

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Brandi L. Williams; Moussa A. Zouache; Nathan A. Seager; Chris M. Pappas; Jin Liu; Robert A. Anstadt; William C. Hubbard; Julie Thomas; Jill L. Hageman; Jennifer Mohler; Burt T. Richards; Gregory S. Hageman
TAGS: htra1 gene, proteins, vitreous body, genetic risk, enzyme-linked immunosorbent assay, age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):34. https://doi.org/10.1167/iovs.65.4.34

Includes: Supplemental Content

Retina April 2024

Drug Distribution After Intravitreal Injection: A Mathematical Model

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Alessia Ruffini; Alessia Casalucci; Caterina Cara; C. Ross Ethier; Rodolfo Repetto
TAGS: drug distribution, eye, injections, intravitreal injections, mathematical model, vitreous body, intraocular pressure, fluid flow, biological transport
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):9. https://doi.org/10.1167/iovs.65.4.9

Retina April 2024

Early Choriocapillaris Loss in a Porcine Model of RPE Cell Debridement Precedes Pathology That Simulates Advanced Macular Degeneration

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Raymond Iezzi; Brittni A. Scruggs; Jarel Gandhi; Francesca N. Zenti; Noah Shafi; Aubrey Berger; Alan D. Marmorstein
TAGS: debridement, macular degeneration, suidae, retinal pigment cell, pathology
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):8. https://doi.org/10.1167/iovs.65.4.8

Includes: Multimedia, Supplemental Content

Retina April 2024

Democratizing Vitreoretinal Surgery Training With a Portable and Affordable Virtual Reality Simulator in the Metaverse

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Fares Antaki; Cedryk Doucet; Daniel Milad; Charles-Édouard Giguère; Benoît Ozell; Karim Hammamji
TAGS: retinal surgery, simulators, training, virtual reality, vitreoretinal surgery, vitrectomy, tissue membrane, surgical procedures, operative, learning
Trans. Vis. Sci. Tech.. 2024; 13(4):5. https://doi.org/10.1167/tvst.13.4.5

Includes: Multimedia, Supplemental Content

Retina April 2024

Degradation of Photopic and Mesopic Contrast Sensitivity Function in High Myopes With Partial Posterior Vitreous Detachment

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Jian Zhao; Minzhi Xiao; Ye Zhu; Qianwen Gong; Jia Qu; Fan Lu; Liang Hu
TAGS: catabolism, contrast sensitivity, vitreous detachment, myopia
Trans. Vis. Sci. Tech.. 2024; 13(4):3. https://doi.org/10.1167/tvst.13.4.3

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2024

Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations

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Erkuan Dai; Min Liu; Shujin Li; Xiang Zhang; Shiyuan Wang; Rulian Zhao; Yunqi He; Li Peng; Liting Lv; Haodong Xiao; Mu Yang; Zhenglin Yang; Peiquan Zhao
TAGS: familial exudative vitreoretinopathies, missense mutation, mutation, proteins, tissue membrane
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):1. https://doi.org/10.1167/iovs.65.4.1

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2024

Forward Light Scattering of the Vitreous Gel After Enzymatic Aging: An In Vitro Model to Study Vitreous Opacification

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Maximilian Hammer; Marcel Muuss; Sonja Schickhardt; Alexander Scheuerle; Ramin Khoramnia; Grzegorz Łabuz; Philipp Uhl; Gerd Uwe Auffarth
TAGS: opacification, vitreous body, aging, bromelains, hyaluronic acid
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):36. https://doi.org/10.1167/iovs.65.3.36

Immunology and Microbiology February 2024

Phylogenetic and Recombination Analysis of Clinical Vitreous Humor–Derived Adenovirus Isolates Reveals Discordance Between Serotype and Phylogeny

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Aaron W. Kolb; Viet Q. Chau; Darlene L. Miller; Nicolas A. Yannuzzi; Curtis R. Brandt
TAGS: adenoviruses, genome, phylogeny, proteins, recombination, genetic, serotype, vitreous body, adenoviruses, human
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):12. https://doi.org/10.1167/iovs.65.2.12

Includes: Supplemental Content

Retina January 2024

Vitreous Biomarkers for Proliferative Vitreoretinopathy Prognostication in Patients Undergoing Primary Retinal Detachment Repair

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Abtin Shahlaee; Daphne Yang; Jamie Chen; Ricardo Lamy; Jay M. Stewart
TAGS: biological markers, detached retina repairs, rhegmatogenous retinal detachment, vitreoretinopathy, proliferative, vitreous body, proteins, vimentin
Trans. Vis. Sci. Tech.. 2024; 13(1):3. https://doi.org/10.1167/tvst.13.1.3

Includes: Supplemental Content

Retina December 2023

Transition to Chronic Fibrosis in an Animal Model of Retinal Detachment With Features of Proliferative Vitreoretinopathy

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Cornelia Peterson; Yuchen Lu; Clayton P. Santiago; Antoinette C. Price; Minda M. McNally; William Schubert; Khaled Nassar; Thomas Zollner; Seth Blackshaw; Charles G. Eberhart; Mandeep S. Singh
TAGS: animal model, fibrosis, gene expression, histology, retinal detachment, rhegmatogenous retinal detachment, tissue membrane, vitreoretinopathy, proliferative, oryctolagus cuniculus, fibrillar collagen
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):39. https://doi.org/10.1167/iovs.64.15.39

Includes: Supplemental Content

Retina December 2023

Correlation Between Vitreous Level of Angiogenic Growth Factors and Oxygen Saturation in Retinal Vessels in Diabetic Retinopathy

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Hana Morin; Jan Havlík; Oldřich Chrapek; Michal Hrevuš; Pavel Němec; Leoš Rejmont; Jan Tesař; Marta Kalousova; Tomaš Zima; Martin Šín
TAGS: angiogenesis, diabetic retinopathy, growth factor, oxygen saturation measurement, retinal vessels, vitreous body, oximetry, vascular endothelial growth factor a, diabetes mellitus
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):4. https://doi.org/10.1167/iovs.64.15.4

Anatomy and Pathology/Oncology December 2023

Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma

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Hiroyuki Komatsu; Yoshihiko Usui; Kinya Tsubota; Risa Fujii; Takefumi Yamaguchi; Kazuichi Maruyama; Ryo Wakita; Masaki Asakage; Kazuki Hamada; Naoyuki Yamakawa; Naoya Nezu; Koji Ueda; Hiroshi Goto
TAGS: primary vitreoretinal lymphoma, proteins, vitreous body, ocular sarcoidosis
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):2. https://doi.org/10.1167/iovs.64.15.2

Includes: Supplemental Content

Anatomy and Pathology/Oncology November 2023

Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation

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Jay Jiyong Kwak; Kwang Seob Lee; Junwon Lee; Yong Joon Kim; Eun Young Choi; Suk Ho Byeon; Won Seok Chang; Yu Ri Kim; Jin Seok Kim; Saeam Shin; Seung-Tae Lee; Sung Soo Kim; Christopher Seungkyu Lee
TAGS: biopsy, massively-parallel genome sequencing, primary vitreoretinal lymphoma, vitreous body, liquid biopsy, genotype-phenotype associations
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):27. https://doi.org/10.1167/iovs.64.14.27

Includes: Supplemental Content

Retina November 2023

Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers

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Gabriel Velez; Julian Wolf; Antoine Dufour; Prithvi Mruthyunjaya; Vinit B. Mahajan
TAGS: biological markers, intraocular melanoma, neoplasms, proteins, proteomics, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):14. https://doi.org/10.1167/iovs.64.14.14

Includes: Supplemental Content

Retina November 2023

Correlation of Aqueous, Vitreous, and Serum Protein Levels in Patients With Retinal Diseases

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Sabine Wilson; Juliane Siebourg-Polster; Bjoern Titz; Zhiwen Jiang; Francois Bartolo; Vincent Lavergne; Javier Gayán; Justus G. Garweg; Sascha Fauser; Andreas Dieckmann
TAGS: biological markers, hypertension, proteins, retinal diseases, vitreous body, aqueous humor
Trans. Vis. Sci. Tech.. 2023; 12(11):9. https://doi.org/10.1167/tvst.12.11.9

Includes: Supplemental Content

Retina October 2023

Silibinin Prevents TGFβ-Induced EMT of RPE in Proliferative Vitreoretinopathy by Inhibiting Stat3 and Smad3 Phosphorylation

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Xinqi Ma; Yiyu Xie; Yajun Gong; Chuxuan Hu; Kairui Qiu; Yao Yang; Huangxuan Shen; Xiaolai Zhou; Chongde Long; Xiaofeng Lin
TAGS: epithelial to mesenchymal transition, phosphorylation, silibinin, smad3 gene, stat3 protein, vitreoretinopathy, proliferative
Invest. Ophthalmol. Vis. Sci.. 2023; 64(13):47. https://doi.org/10.1167/iovs.64.13.47

Includes: Supplemental Content

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Aqueous VEGF-A Levels as a Liquid Biopsy Biomarker of Retinoblastoma Vitreous Seed Response to Therapy

Complement Cascade 8 - Alpha and Calpain-2 in Extracellular Vesicles of Human Vitreous as Biomarkers of Infectious Endophthalmitis

Light Scattering by Vitreous of Humans With Vision Degrading Myodesopsia From Floaters

Short Term Effect of Pre-Operative Anti-VEGF on Angiogenic and Fibrotic Profile of Fibrovascular Membranes of Proliferative Diabetic Retinopathy

Levels of the HtrA1 Protein in Serum and Vitreous Humor Are Independent of Genetic Risk for Age-Related Macular Degeneration at the 10q26 Locus

Drug Distribution After Intravitreal Injection: A Mathematical Model

Early Choriocapillaris Loss in a Porcine Model of RPE Cell Debridement Precedes Pathology That Simulates Advanced Macular Degeneration

Democratizing Vitreoretinal Surgery Training With a Portable and Affordable Virtual Reality Simulator in the Metaverse

Degradation of Photopic and Mesopic Contrast Sensitivity Function in High Myopes With Partial Posterior Vitreous Detachment

Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations

Forward Light Scattering of the Vitreous Gel After Enzymatic Aging: An In Vitro Model to Study Vitreous Opacification

Phylogenetic and Recombination Analysis of Clinical Vitreous Humor–Derived Adenovirus Isolates Reveals Discordance Between Serotype and Phylogeny

Vitreous Biomarkers for Proliferative Vitreoretinopathy Prognostication in Patients Undergoing Primary Retinal Detachment Repair

Transition to Chronic Fibrosis in an Animal Model of Retinal Detachment With Features of Proliferative Vitreoretinopathy

Correlation Between Vitreous Level of Angiogenic Growth Factors and Oxygen Saturation in Retinal Vessels in Diabetic Retinopathy

Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma

Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation

Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers

Correlation of Aqueous, Vitreous, and Serum Protein Levels in Patients With Retinal Diseases

Silibinin Prevents TGFβ-Induced EMT of RPE in Proliferative Vitreoretinopathy by Inhibiting Stat3 and Smad3 Phosphorylation

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